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The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical(More)
Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast(More)
OBJECTIVE To study cytosolic cathepsin D behavior and possible relationship with other clinical and biological parameters in women affected by breast invasive ductal carcinomas and older than 70 years (range: 71-88). MATERIAL AND METHODS cytosolic levels of cathepsin D were determined by an Immunoradiometric Assay (IRMA-CIS France). Clinical and(More)
  • J I Arias, R H Barbá, J Maíz Apellániz, N I Morrell, M Rubio
  • 2005
A detailed study of the Hourglass Nebula in the M8 star forming region is presented. The study is mainly based on recent subarcsec-resolution JHK s images taken at Las Campanas Observatory and complemented with archival HST images and longslit spectroscopy retrieved from the ESO Archive Facility. Using the new numerical code CHORIZOS, we estimate the(More)
Breast cancer is currently becoming a disease of the elderly. We have studied the relation between CA 15.3 serum concentrations and clinical-pathological parameters in 69 women with IDC aged over 70 years (76.3±4.2; range: 71-88; median 76). A group of 205 women with the same tumor but aged <70 years (62.8±4.0; range: 55-70; median 63) was also considered(More)
  • D Minniti, P W Lucas, J P Emerson, R K Saito, M Hempel, P Pietrukowicz +33 others
  • 2009
We describe the public ESO near-IR variability survey (VVV) scanning the Milky Way bulge and an adjacent section of the mid-plane where star formation activity is high. The survey will take 1929 hours of observations with the 4-metre VISTA telescope during five years (2010 − 2014), covering ∼ 10 9 point sources across an area of 520 deg 2 , including 33(More)
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