José Ignacio Andrés

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Group formation is a key aspect in computer-supported col-laborative learning, since different characteristics of students might influence the group performance. In this article, we present an assistant that models group formation as a weighted constraint satisfaction problem (WCSP), and considers three students' features, namely: psychological styles, team(More)
  • J Andrés, Díaz Pace, F Trilnik, Marcelo R Campo
  • 2000
Concerns in software applications can range from general-purpose concerns such as tracing, synchronization or error handling, to more specific ones such as scheduling in simulation domains or time constraints in real-time systems. An appropriate separation of concerns is supposed to reduce software complexity and improve software evolution, by keeping track(More)
Advanced leads from a series of 1,2,4-triazolo[4,3-a]pyridines with mGlu2 receptor PAM activity are reported. By modification of the analogous imidazo[1,2-a]pyridine series, the newly reported leads have improved potency, in vitro ADMET, and hERG as well as good in vivo PK profile. The optimization of the series focused on improving metabolic stability(More)
UNLABELLED Phosphodiesterases are enzymes that inactivate the intracellular second messengers 3',5'-cyclic adenosine-monophosphate and/or cyclic guanosine-monophosphate. Of all 11 known phosphodiesterase families, phosphodiesterase-10A (PDE10A) has the most restricted distribution, with high expression in the striatum. PDE10A inhibitors are pursued as drugs(More)
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia among the elderly population. The good correlation of the density and neocortical spread of neurofibrillary tangles (NFTs) with clinical AD disease progression offers an opportunity for the early diagnosis and staging using a noninvasive imaging technique(More)
INTRODUCTION In vivo visualization of PDE10A using PET provides a tool to evaluate the role of PDE10A in various neuropsychiatric diseases and can also be useful in the clinical evaluation of PDE10A inhibitor drug candidates. We evaluated several carbon-11 and fluorine-18 labeled PDE10A inhibitors as potential PDE10A PET radioligands. MATERIALS & METHODS(More)
Advanced leads of an imidazopyridine series of positive allosteric modulators of the metabotropic glutamate 2 (mGlu2) receptor are reported. The optimization of in vitro ADMET and in vivo pharmacokinetic properties led to the identification of 27o. With good potency and selectivity for the mGlu2 receptor, 27o affected sleep-wake architecture in rats after(More)
  • J Andrés, Díaz Pace, Luis S Berdún, Analia A Amandi, Marcelo R Campo
  • 2005
Object-oriented patterns are enjoying much popularity as mechanisms to address flexibility and reusability in object-oriented designs. Consequently , many CASE environments have incorporated different pattern-based facilities. Nonetheless, the selection of the most appropriate patterns for a given design context is left to the developer's criteria. For(More)
The aims of this study were: (1) to investigate the evolution of the sleep pattern in preterm newborns during their first month of life; (2) to assess the influence of light-dark on the sleep pattern; and (3) to compare this pattern with that of full-term newborns. The population consisted of 60 healthy, preterm newborns and 63 full-term newborns, divided(More)