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BACKGROUND Osteoprotegerin (OPG), a secreted member of the tumour necrosis factor receptor superfamily of cytokines, has been associated with endothelial dysfunction. We studied in type 2 diabetic and/or hypertensive patients the relationship between serum OPG and vascular alterations associated with these pathologies. MATERIALS AND METHODS We analysed(More)
OBJECTIVE To analyze the reliability and validity of a semiautomated tool for assessing retinal vessel caliber and to describe the relationship of measures taken to cardiovascular risk and target organ damage. METHODS A total of 210 patients aged 34-75 years were selected with retinography. Retinal photographs were digitized, and superior and inferior(More)
Increased arterial stiffness has been shown to predict cardiovascular risk in hypertensive patients. Our objective was to evaluate the relationship between the ambulatory arterial stiffness index (AASI) and subclinical organ damage (SOD). The design was a cross-sectional study. Subjects included 554 hypertensive patients with and without drug treatment(More)
BACKGROUND Endoglin is involved in the regulation of endothelial function, but there are no studies concerning its relation with hypertension- and diabetes-associated pathologies. Thus, we studied the relationship between plasma levels of soluble endoglin and cardiovascular alterations associated with hypertension and diabetes. METHODS We analyzed 288(More)
OBJECTIVES To analyze the relationship of 24-h blood pressure variability (BPV) with vascular structure and function using the SD and the coefficient of variation (CV). PATIENTS AND METHODS A cross-sectional study was carried out in 344 hypertensive patients (aged 54.1±11.7 years, 59.6% men). BPV was estimated with the SD and CV over 24-h, both awake and(More)
BACKGROUND The present study was designed to evaluate the relationship between high-sensitivity C-reactive protein (hs-CRP) and arterial stiffness according to sex in patients with arterial hypertension. METHODS A case-series study was carried out in 258 hypertensive patients without antecedents of cardiovascular disease or diabetes mellitus. Nephelometry(More)
BACKGROUND Aging has been associated with an increase in arterial stiffness. We analyzed the relationship between regular physical activity and cardiovascular aging evaluated by the radial augmentation index (rAIx), ambulatory arterial stiffness index (AASI), pulse pressure (PP) and heart age in subjects without atherosclerotic disease. METHODS A(More)
BACKGROUND Our aim was to analyze the relationship between abdominal obesity and general obesity, with subclinical atherosclerosis, arterial stiffness and wave reflection in healthy, diabetics and hypertensive subjects. METHODS A cross-sectional descriptive study was made of 305 individuals (diabetics 32.8%, hypertensive subjects 37.0% and healthy(More)
OBJECTIVES The purpose of this study was to analyse the relationship between sodium and potassium intake and vascular structure and function and to ascertain whether said relationship follows the pattern of a J-shaped curve. METHODS A cross-sectional study was carried out in a primary care setting. Three hundred fifty-one subjects from the Vasorisk study(More)
BACKGROUND The cardio ankle vascular index (CAVI) is a new index of the overall stiffness of the artery from the origin of the aorta to the ankle. This index can estimate the risk of atherosclerosis. We aimed to find the relationship between CAVI and target organ damage (TOD), vascular structure and function, and cardiovascular risk factors in Caucasian(More)