José Humberto Damante

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Radiotherapy, alone or associated with surgery or chemotherapy, produces a significant increase in cure rates for many malignancies of the head and neck region. However, high doses of radiation in large areas, including the oral mucosa, may result in several undesired reactions that manifest during or after the completion of therapy. The multidisciplinary(More)
Oral squamous cell carcinoma (OSCC) is a cancerous lesion with high incidence worldwide. The immunoregulatory events leading to OSCC persistence remain to be elucidated. Our hypothesis is that regulatory T cells (Tregs) are important to obstruct antitumor immune responses in patients with OSCC. In the present study, we investigated the frequency, phenotype,(More)
OBJECTIVE The objective of this study was to investigate the effects of gastroesophageal reflux disease (GERD) on dentition, salivary function, and oral mucosa. STUDY DESIGN Thirty-one patients with esophagitis underwent medical evaluation, which included taking their medical history, performing both an esophagogastroduodenoscopy and esophagus biopsy, and(More)
A 62-year-old woman sought treatment for a red macule in her hard palate. Examination of the oral cavity revealed an ovoid-shaped erythematous macule on the right side of the hard palate. The patient was edentulous and used a poorly adapted maxillary denture. The initial diagnosis was chronic atrophic candidosis and trauma; however, when the lesion did not(More)
The aim of this study was to evaluate the oral sequelae of radiotherapy in patients treated between 1999 and 2003 for head and neck tumors. One-hundred patients (24 women, 76 men) ranging in age from 30 to 83 years (mean 59.2 years) were examined. Time since radiotherapy ranged from 1 to 72 months (mean 28 months). The total mean radiation dose received by(More)
OBJECTIVES The aim of this study was to investigate the relationship between podoplanin expression and proliferative activity of ameloblastomas and remnants of the odontogenic epithelium from dental follicles (DF) of unerupted teeth. SUBJECTS AND METHODS Thirty-three paraffin-embedded ameloblastomas and thirty-two DF obtained of unerupted teeth were(More)
Congenital granular cell lesion of the newborn, also known as congenital epulis, is a rare benign oral cavity tumor presenting at birth. Usually, it appears as a solitary mass arising in the mouth and originates from the anterior alveolar ridge. The objective of the present article is to report a case of congenital granular cell lesion in an 8-day-old(More)
UNLABELLED Although some morphological investigations on aged human sublingual glands (HSG) found eventual phenomena identified as autolysis and mucous extravasation, the exact meaning of these findings has not been elucidated. OBJECTIVE The aim of this work is to investigate whether acinar autolysis and mucous extravasation are related to the aging(More)
PD-1 and PD-L1 can be involved in tumor escape, and little is known about the role of these molecules in oral tumors or pre-malignant lesions. In the present study, we investigated the expression of PD-1 and PD-L1 in the blood and lesion samples of patients with actinic cheilitis (AC) and oral squamous cell carcinoma (OSCC). Our results showed that(More)
OBJECTIVE To determine whether spontaneous resolution of simple bone cysts (SBC) is possible. METHODS Ten patients were diagnosed as SBC on clinical and radiographic criteria and followed up for 1 to 7 years (mean 3.8). The degree of resolution was assessed subjectively by four radiologists and objectively by changes in the grey level histogram. RESULTS(More)