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BACKGROUND Omeprazole is metabolized by the hepatic cytochrome P450 (CYP) 2C19 enzyme to 5-hydroxyomeprazole. CYP2C19 exhibits genetic polymorphisms responsible for the presence of poor metabolizers (PMs), intermediate metabolizers (IMs) and extensive metabolizers (EMs). The defective mutations of the enzyme and their frequencies change between different(More)
In the 70s, reports began to appear of phenolic metabolites of brown algae with the characteristics of tannins; these compounds, initially termed phaeophyte tannins, marine algal polyphenols or polyphloroglucinols, are known as phlorotannins, the youngest group of plant polyphenolics. Despite over 40 years of research in phlorotannins, this area is still in(More)
The Melastomataceae family, the seventh largest flowering plants, has been studied in several fronts of natural product chemistry, including terpenoids, simple phenolics, flavonoids, quinones, lignans and their glycosides, as well as a vast range of tannins or polyphenols. This review concerns the phenolic and polyphenolic metabolites described in the(More)
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