José Gaal

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Pheochromocytomas (PCCs) are neuroendocrine tumors arising from chromaffin cells of the adrenal medulla. Related tumors that arise from the paraganglia outside the adrenal medulla are called paragangliomas (PGLs). PCC/PGLs are usually benign, but approximately 17% of these tumors are malignant, as defined by the development of metastases. Currently, there(More)
BACKGROUND In pediatric neuroblastoma (NBL), high anaplastic lymphoma kinase (ALK) levels appear to be correlated with an unfavorable prognosis, regardless of ALK mutation status. This suggests a therapeutic role for ALK inhibitors in NBL patients. We examined the correlation between levels of ALK, phosphorylated ALK (pALK) and downstream signaling proteins(More)
BACKGROUND Catecholamine-producing tumours are called pheochromocytomas when they are located in the adrenal gland and sympathetic paragangliomas when they are located elsewhere in the abdomen. Rarely these tumours do not produce catecholamines and even more rarely they arise in the spermatic cord. Over the past decade, systematic mutation analysis of(More)
Cover: succinate dehydrogenase protein. Design en layout: Frank van der Panne. José Gaal geboren te Dordrecht. I'm a great believer in luck and I find the harder I work, the more I have of it. 1.4 HIF pathway 27 1.5 Aims and outline of this thesis 29 Part I Dissection of genetic background by immunohistochemical analysis. Chapter 2 A routine(More)
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