José G.B. Derraik

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We aimed to evaluate insulin secretion and insulin sensitivity in adults born preterm and their children. Subjects were adults born both preterm and at term, with their children aged 5-10 years born at term. Insulin sensitivity and secretion were assessed using hyperglycemic clamps in adults and frequently sampled intravenous glucose tolerance tests using(More)
Aims This study aimed to assess the incidence of new-onset diabetic ketoacidosis (DKA) incidence over a 15-year period in children with type 1 diabetes (T1DM) from our regional paediatric diabetes centre in Auckland, New Zealand. Methods We performed a retrospective review of all patients <15 years of age diagnosed with T1DM from our unselected complete(More)
Hyperemesis gravidarum leads to alterations in maternal (and possibly fetal) nutrition throughout pregnancy, but there are no data on the long-term metabolic health outcomes in the offspring. We hypothesized that hyper-emesis gravidarum could lead to fetal nutritional compromise or physiological stress, which may programme later metabolism and body(More)
Despite marked improvements in developmental outcome with newborn screening and early levothyroxine replacement most follow up studies of congenital hypothyroidism (CH) show a persistent mild deficit in total IQ. It has been considered that these deficits in neurocognitive function occur in utero and thus even early therapy cannot completely normalise(More)
We hypothesized that losartan would help in achieving clinical remission in CED (Camurati Engelmann Disease) patients by blocking TGFB1(transforming growth factor beta 1) with fewer side-effects than steroids. CED characterised by progressive diaphyseal dysplasia is associated with debilitating bone pain in the limbs, muscle weakness, fatiguability and(More)
We recently showed from a Swedish cohort that nearly half of boys born post-term (≥42 weeks gestation) were overweight or obese at 16 years of age. We hypothesized that post-term children would display features of insulin resistance and the metabolic syndrome even in their pre-pubertal years. 90 healthy pre-pubertal children aged 4–11 years, with birth(More)
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