José Eymard Homem Pittella

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We studied at the biochemical, morphological, and behavioral levels the effect of chronic ethanol consumption, associated or not with a mild thiamine deficiency episode. We found that (i) thiamine deficiency induced a significant decrease of the acetylcholinesterase (AChE) activity both in cortex and hippocampus; (ii) chronic ethanol treatment has no effect(More)
This morphometric, quantitative and correlative multivariate study of the hippocampal formation in human brains from two distinct normal aging populations provides an additional support to the notion that neuritic plaques (NP) are an earlier stage of the pathological process underlying neurofibrillary tangle (NFT) formation. It is shown that the rate of(More)
Parasitic infections of the central nervous system (CNS) include two broad categories of infectious organisms: single-celled protozoa and multicellular metazoa. The protozoal infections include malaria, American trypanosomiasis, human African trypanosomiasis, toxoplasmosis, amebiasis, microsporidiasis, and leishmaniasis. The metazoal infections are grouped(More)
A case of pontoneocerebellar hypoplasia (PNCH) in a 9-day-old child--the youngest in the literature--is described. Right after birth the child showed serious respiratory insufficiency and developed frequent episodes of apnea and cardiorespiratory arrests, dying on the 9th day. Postmortem examination showed significant alterations only in the brain. There(More)
We describe the unusual case of a 45-year-old male patient harboring an intracranial mass due to cerebral amyloid angiopathy whose clinical and radiological features were those of a low grade glioma. Biopsy revealed cerebral amyloid angiopathy. The clinical, radiological and pathological findings are discussed as we review the available literature.
Eleven out of 36 autopsied cases of Wernicke's encephalopathy had developed coma. None of these patients had the diagnosis during life. There were six men and five women with ages ranging from 26 to 50 years (mean 36.6). Seven of these patients were heavy drinkers, three exhibited signs of severe malnutrition, whereas one was being evaluated for a(More)
The brains of 46 patients with hepatosplenic schistosomiasis mansoni were studied. Eggs of Schistosoma mansoni were found in 12 brains (26 per cent). The parasite location, brain reaction, clinical features and the possible paths by which the eggs of S. mansoni reach the nervous system are discussed. Our data and those of the literature suggest that brain(More)
We describe four cases of the tumoral form of cerebral schistosomiasis mansoni. The patients had symptoms of increased intracranial pressure and focal neurological signs that varied according to the site of the lesion. Computerized tomography showed a hyperdense, enhancing lesion located in the cerebellum (2 patients), frontal lobe and thalamus (1 patient),(More)
A 47-year-old man with a six-month history of progressive tetraparesis and sphincter disturbances developed tetraplegy after two years and died. A cervical MRI revealed an ill-defined, enhancing lesion from C1 to C6, internally attached to the dura mater and compressing the spinal cord. At necropsy, eight whitish nodes and diffuse thickening of the dura(More)
We present an anatomopathologic study of a case of partial fusion of the mamillary bodies in a 57-year-old man with no neurologic or neuropsychiatric change. Medial nuclei were fused. Remaining nuclei and afferent and efferent connections were preserved. The comparison of this case with other similar malformations suggests the possibility of disturbances in(More)