José Carlos Martín

Learn More
Seventy-nine Sprague-Dawley derived primimparous rats were injected subcutaneously throughout pregnancy and the nursing period with either (1) 30 mg/kg of pure nicotine, (2) 5.0 mg/kg methamphetamine HCL, (3) saline vehicle, or, (4) non-injected. Vital and developmental measures were taken on the offspring throughout the nursing period and for one(More)
The teratogenicity of alcohol has been demonstrated in humans through clinical studies, behavioral studies, and epidemiologic studies, and in animals through controlled laboratory experiments. In humans exposed to alcohol during gestation the effects can range from fetal alcohol syndrome in some offspring of chronic alcoholic women to reduced average birth(More)
An unselected sample of 1529 women (predominantly white, married, and middle-class) were interviewed during pregnancy regarding their use of alcohol, nicotine, caffeine, drugs, and other variables. Subsets of offspring were examined to assess the relationship of self-reported maternal alcohol use to infant health and development. Multiple regression(More)
This substudy of a longitudinal prospective study was designed to assess neurodevelopmental and neurobehavioral performance in newborn infants who were maternally exposed to cocaine and other drugs of abuse or the other drugs without cocaine. Sample selection procedures were designed to permit statistical control for marijuana, alcohol, and tobacco. Cocaine(More)
Twenty-five Sprague-Dawley derived rats were administered 1.0, 3.0 or 5.0 mg/kg of methamphetamine HC1 or saline twice daily throughout gestation beginning on Day 1 of pregnancy. Rats were allowed to deliver normally; offspring were culled to 8 and sexed on Day 7, and weaned on Day 21. All females had viable litters except at the 5.0 mg/kg dose where 4 of 7(More)
  • J C Martin
  • 1982
Smoking and caffeine ingestion are the most commonly abused physiologically addictive licit drugs [32]. They have similar neurally facilitative properties and individuals monitor their intake so as to maintain a constant level in blood. As is true of other addictive drugs, tolerance to their effects develops over time resulting in increased consumption.(More)
Sixty-eight Sprague-Dawley derived primiparous rats were injected subcutaneously twice daily throughout pregnancy and the nursing period with either (1) 3.0 mg/kg of pure nicotine, (2) 5.0 mg/kg methamphetamine HCl, or (3) saline vehicle. Locomotor activity was monitored one night/month from 3-39 months of age in randomly selected male offspring.(More)
  • J C Martin
  • 1986
Neurobiological and functional changes in mature and aging rodents following intrauterine exposure to tobacco products, amphetamine and the barbiturates are reviewed. The types of behavior surveyed include activity, maze learning, steady state performance, and passive and active avoidance. Hormonal and neurochemical changes are discussed as well. Two(More)