José Carlos Antoranz

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BACKGROUND Diastolic suction is a major determinant of early left ventricular filling in animal experiments. However, suction remains incompletely characterized in the clinical setting. METHODS AND RESULTS First, we validated a method for measuring the spatio-temporal distributions of diastolic intraventricular pressure gradients and differences (DIVPDs)(More)
BACKGROUND AND AIM OF THE STUDY Because the hemodynamic basis of aortic valve area (AVA) has never been validated in vivo, several alternative indices have been proposed to quantify the severity of aortic stenosis (AS). This study was designed to assess the fluid-dynamics of aortic valve stenosis in order to clarify which index best accounts for disease(More)
BACKGROUND Ejection intraventricular pressure gradients are caused by the systolic force developed by the left ventricle (LV). By postprocessing color Doppler M-mode (CDMM) images, we can measure noninvasively the ejection intraventricular pressure difference (EIVPD) between the LV apex and the outflow tract. This study was designed to assess the value of(More)
BACKGROUND During late ejection, myocardial relaxation causes systolic flow to decelerate and stop, and this phenomenon is coupled with the generation of a pressure gradient inside the left ventricle (LV). We hypothesized that the peak reverse ejection intraventricular pressure difference (REIVPD) between the LV apex and the outflow tract could be a useful(More)
OBJECTIVES The study was designed to validate in vivo a new method to measure ejection intraventricular pressure gradients (IVPGs) by processing color M-mode Doppler data and to assess the effects of inotropic interventions on IVPGs in the clinical setting. BACKGROUND In the absence of obstruction, ejection IVPGs cannot be estimated by Doppler using the(More)
Reliable noninvasive estimators of global left ventricular (LV) chamber function remain unavailable. We have previously demonstrated a potential relationship between color-Doppler M-mode (CDMM) images and two basic indices of LV function: peak-systolic elastance (E<sub>max </sub>) and the time-constant of LV relaxation (tau). Thus, we hypothesized that(More)
This paper presents a methodology and a software package developed to quantify M-mode tissue Doppler imaging (TDI), defining a number of quantitative parameters drawn from velocity and gradient curves obtained after segmenting the myocardial wall into anatomical layers. The independent clinical predictive value of these parameters to detect motion(More)
In cardiovascular research, relaxation and stiffness are calculated from pressure-volume (PV) curves by separately fitting the data during the isovolumic and end-diastolic phases (end-diastolic PV relationship), respectively. This method is limited because it assumes uncoupled active and passive properties during these phases, it penalizes statistical(More)
Doppler assessment of intracardiac pressure gradients using the simplified Bernoulli equation is inaccurate in the absence of a restricted orifice. The purpose of this study is to develop a new general method to map instantaneous pressure gradients inside the heart using Doppler echocardiography. Color Doppler M-mode recordings are digitally postprocessed(More)
An on-lattice Monte Carlo model is implemented for the simulation of particle deposit growth by advection and diffusion towards a flat surface. The particle deposit structure is characterized by its bulk (density) and interface (mean height and surface width) properties. Numerical correlations, fitted by simple expressions, are reported for these(More)