José C. Tohá

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A method for fast nucleotide sequencing is described. It is based in the selection of well-known small oligomers able to be hybridized with the unknown target. The selected oligomers are afterwards ordered following a simple statistical approach. The use of capillary electrophoresis for the analysis is emphasized.
An algorithm for medical diagnosis assistance is described. In this algorithm, the patient is identified following the simultaneous evaluation of its degree of similarity with a given disease, as well as the extent of disagreement with the rest of diseases considered in the differential diagnosis. In an example the algorithm is applied to the diagnosis(More)
We present a new method for protein secondary structure prediction, based on the recognition of well-defined pentapeptides, in a large databank. Using a databank of 635 protein chains, we obtained a success rate of 68.6%. We show that progress is achieved when the databank is enlarged, when the 20 amino acids are adequately grouped in 10 sets and when more(More)
A new cryptology that uses biomolecules as carriers of hidden information is described here. The huge dimension of biopolymers permits the insertion there of private messages and the rapidity and specificity of biomolecular interactions facilitate the identification of classified communications. Otherwise, this process can be implemented in a virtual(More)
Between a group of non sulphydryl radioprotectors (methanol, formaldehyde, acetaldehyde, formiate, acetate, ethanol and tryptophan) ; ethanol and tryptophan were selected because its high protector action on irradiated purine and pyrimidine bases. At molarities of the order of 10~4 for tryptophan-ethanol and bases and DNA the respective DRF values were: for(More)
In the i n t e r p r e t a t i o n of the codon e v o l u t i o n the hypo the s i s of the g e n e r a t i o n of p r i m o r d i a l t r i p l e t s as a consequence of a " f r o z e n a c c i d e n t p robably p r e v a i l s . On the o t h e r hand, T.H. Jukes (1983), based on the s t r u c t u r e of the mammalian m i tochondr ia l code, suggested the(More)