José C. Romero Cortés

Learn More
IL-4 is involved in several human diseases including allergies, autoimmunity, and cancer. Its effects are mainly mediated through the transcription factor STAT6. Therefore, investigation of compounds that regulate STAT6 activation is of great interest for these diseases. Natural polyphenols are compounds reported to have therapeutic properties in diseases(More)
BACKGROUND Allergic diseases have a major health care impact in industrialized countries. The development of these diseases is influenced by exposure to allergen and to immunological and genetic factors. However, the molecular mechanisms underlying the inflammatory response that triggers allergy are not well defined. OBJECTIVE We have investigated the(More)
Bacterial LPS (endotoxin) has been implicated in the pathogenesis of acute liver disease through its induction of the proinflammatory cytokine TNF-α. TNF-α is a key determinant of the outcome in a well-established mouse model of acute liver failure during septic shock. One possible mechanism for regulating TNF-α expression is through the control of protein(More)
Although FoxP3(+) regulatory T cells are key players in the maintenance of immune tolerance and autoimmunity, the lack of specific markers constitute an obstacle to their use for immunotherapy protocols. In this study, we have investigated the role of the C-type lectin receptor CD69 in the suppressor function of Tregs and maintenance of immune tolerance(More)
Bacterial LPS (endotoxin) has been implicated in the pathogenesis of acute liver disease through its induction of the proinflammatory cytokine TNF-α. TNF-α is a key determinant of the outcome in a well-established mouse model of acute liver failure during septic shock. One possible mechanism for regulating TNF-α expression is through the control of protein(More)
PURPOSE OF REVIEW Once an obscure disease, recent studies have transformed our understanding of angioimmunoblastic T-cell lymphoma (AITL). In this review, we summarize new major advances in the genetics and biology of AITL. RECENT FINDINGS Genome wide sequencing studies have dissected the repertoire of the genetic alterations driving AITL uncovering a(More)
A fuzzy Bayesian approach helping the Internet user to filter Web pages is discussed. In the proposed approach, one page can be classified as having the continuous quality of being interesting, this means that a certain grade of membership can be associated with each page relative to a category of selection. Filtering is based on the evidences of the(More)
Alexander V. Smirnov, Leonid B. Sheremetov, Nikolai Chilov, Jose Romero Cortes St.Petersburg Institute for Informatics and Automation of the Russian Academy of Sciences SPIIRAS, 39, 14 Line, St.Petersburg, 199178, Russia e-mail: smir@.iias.spb.su 2 Computer Science Research Center of National Technical University (CIC-IPN), Av. Juan de Dios Batiz esq. Othon(More)