José C. M. Duque

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OBJECTIVE The use of colonoscopy as a primary screening test for colorectal cancer (CRC) in average risk adults is a subject of controversy. Our primary objective was to build a predictive model based on a few simple variables that could be used as a guide for identifying average risk adults more suitable for examination with colonoscopy as a primary(More)
BACKGROUND Colorectal tumors caused by failure of the DNA mismatch repair system commonly show microsatellite instability. Our goals were to compare the performance of two panels of markers (a panel previously recommended by the National Cancer Institute [NCI] and a pentaplex of mononucleotide repeats) and to devise the simplest diagnostic strategy for(More)
PURPOSE Previous publications have linked Herbalife® products to hepatotoxicity. The identification of earlier cases in which the culprit agent could not be established raised the hypothesis of a possible contamination of some specific batches of Herbalife products. METHODS We searched the Spanish Pharmacovigilance Centres' database of adverse reactions(More)
AIMS To determine risk factors for active tuberculosis in patients with inflammatory bowel diseases. METHODS Retrospective, case-control study at 4 referral hospitals in Spain. Cases developed tuberculosis after a diagnosis of inflammatory bowel disease. Controls were inflammatory bowel disease patients who did not develop tuberculosis. For each case, we(More)
Abstract. In this work, we study the convergence of the finite element method when applied to the following parabolic equation: ut = div(|u|γ(x)∇u) + f(x, t), x ∈ Ω ⊂ Rm, t ∈]0, T ]. Since the problem may be of degenerate type, we utilize an approximate problem, regularized by introducing a parameter ε. We prove, under certain conditions on γ and f , that(More)
In this work, we study the convergence of the finite element method when applied to the following parabolic equation: u t = div(|u| γ(x) ∇u) + λ|u| σ(x,t)−2 u + f (x, t), x ∈ Ω ⊂ R d , t ∈]0, T ]. Since the equation may be of degenerate type, we utilize an approximate problem , regularized by introducing a parameter ε. We prove, under certain conditions on(More)