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Specific binding of glucagon-like peptide (GLP)-1(7-36)amide was detected in several rat brain areas, with the highest values being found in hypothalamic nuclei and the nucleus of the solitary tract. In hypothalamus and brainstem homogenate binding of 125I-GLP-1(7-36)amide was time, temperature, and protein content dependent and was inhibited by unlabeled(More)
Protein structure prediction (PSP) is an open problem with many useful applications in disciplines such as medicine, biology and biochemistry. As this problem presents a vast search space and the analysis of each protein structure requires a significant amount of computing time, it is necessary to take advantage of high-performance parallel computing(More)
Glucagon-like peptide-1(7-36)amide (GLP-1(7-36)amide) and its own receptor have been found in the hypothalamus and brain stem of the rat. In an attempt to gain further insight into the role of this peptide in brain functioning we investigated the effects of GLP-1 (7-36)amide on the release of excitatory amino acid neurotransmitters by the ventromedial(More)
Affymetrix High Oligonucleotide expression arrays, also known as Affymetrix GeneChips, are widely used for the high-throughput assessment of gene expression of thousands of genes simultaneously. Although disputed by several authors, there are non-biological variations and systematic biases that must be removed as much as possible before an absolute(More)
The protein structure prediction (PSP) problem is considered an open problem as there is no recognized " best " procedure to find solutions. Moreover, this problem presents a vast search space and the analysis of each protein conformation requires significant amount of computing time. We propose a reduction of the search space by using the dependent rotamer(More)
The action of luteinizing hormone on topoisomerase I activity from rat Leydig cells was studied. Stimulation of the enzyme was observed after long-term (24 and 48 h) gonadotrophin treatment in in vivo experiments. No change could be detected for shorter times than 12 h using two different experimental approaches. Topoisomerase I was stimulated by cAMP in a(More)