José Antonio López Guerrero

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During the first 6 years of the Program of Genetic Counselling in Cancer of Valencia (eastern Spain), 310 mutations (155 in BRCA1 and 155 in BRCA2) in 1,763 hereditary breast (BC) and ovarian cancer (OC) families were identified. Of the mutations found 105 were distinct (53 in BRCA1 and 52 in BRCA2), eight new and 37 recurrent. Two of the novel mutations(More)
BACKGROUND AND PURPOSE The widespread use of aspirin requires clarification of the aspirin resistance phenomenon. Most studies on this field are focused on patients which may affect the action of aspirin. METHODS We evaluated the biological efficacy of aspirin in healthy subjects. RESULTS Agonist-induced platelet aggregation was fully abrogated by 100(More)
The study aims to identify the relevance of immunohistochemistry (IHC), copy number aberrations (CNA) and epigenetic disorders in BRCAness breast cancers (BCs). We studied 95 paraffin included BCs, of which 41 carried BRCA1/BRCA2 germline mutations and 54 were non hereditary (BRCAX/Sporadic). Samples were assessed for BRCA1ness and CNAs by Multiplex(More)
Studies of morphometric variation make it possible to delimit species and geographic intraspecific variation, mainly in species with wide distribution ranges. In the Neotropical otter, Lontra longicaudis, variation in the shape of the rhinarium of three potential subspecies has been described but it is not known whether there is a pattern to the(More)
Convalescence after surgery is characterized by a period of fatigue (POF). If we assume that the POF syndrome has a multifactorial etiology, it is clear that the aim of therapeutic measures should be to reduce the response to surgical stress. The purpose of the present study was to determine if administering exogenous human growth hormone (hGH) can prevent(More)
Developmental haemostatic studies may help identifying new elements involved in the control of key haemostatic proteins like antithrombin, the most relevant endogenous anticoagulant. In this study, we showed a significant reduction of sialic acid content in neonatal antithrombin compared with adult antithrombin in mice. mRNA levels of St3gal3 and St3gal4,(More)
Size-standardized craniometric variation was investigated among species of the genus Artibeus. Eleven extant and one extinct species were examined using geometric and linear morphometric analyses to evaluate morphological differences among species. Based on 19 landmarks located in the ventral side of the cranium, 29 size-standardized linear measurements(More)
A new species of nematode, Pterygodermatites (Pterygodermatites) mexicana n. sp., is described based on specimens recovered from the intestine of the gray sac-winged bat, Balantiopteryx plicata (Chiroptera, Emballonuridae), from the Biosphere Reserve "Sierra de Huautla" in the state of Morelos, Mexico. This is the second species in the genus described from(More)
OBJECTIVE This article presents and discusses a new surgical abdominal technique for the treatment of posthysterectomy vaginal vault prolapse. METHOD It provides support of the peritoneal surface of the pelvic floor by means of a Gore-Tex mesh, which closes this space. The vaginal vault is fixed to the centre of the mesh. STUDY DESIGN Descriptive study.(More)