José António Miranda

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Improving stress tolerance is a major goal for agriculture. Trehalose is a key molecule involved in drought tolerance in anhydrobiotic organisms. Here we describe the construction of a chimeric translational fusion of yeast trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase. This construct was overexpressed in yeast cells displaying both(More)
Reluctance to recommend lung cancer surgery for octogenarians is partly based on the expectation that the rate of complications and mortality is higher in this group of patients, and on the impression that the life expectancy of an octogenarian with lung cancer is limited by death from natural causes. Moreover, the belief that radiation therapy and(More)
The Saffman-Taylor problem addresses the morphological instability of an interface separating two immiscible, viscous fluids when they move in a narrow gap between two flat parallel plates (Hele-Shaw cell). In this work, we extend the classic Saffman-Taylor situation, by considering the flow between two curved, closely spaced, concentric spheres (spherical(More)
We perform a detailed numerical study of the evolution of a miscible fluid droplet in a time-dependent gap Hele-Shaw cell. The development of the emerging fingering instabilities is systematically analyzed by intensive and highly accurate numerical simulations. We focus on the influence of three relevant physical parameters on the interface dynamics: the(More)
A modified version of the usual viscous fingering problem in a radial Hele-Shaw cell with immiscible fluids is studied by intensive numerical simulations. We consider the situation in which the fluids involved are miscible, so that the diffusing interface separating them can be driven unstable through the injection or suction of the inner fluid. The system(More)
After formation of fungus ball in pre-existing cavities, antifungal agents are very hard to control the infection. Surgical resection offers the only realistic chance of a permanent cure for aspergilloma. However, surgical indications are still a controversy because of the high incidence of postoperative complications. The purpose of this study was to(More)
In patients with non-rheumatic atrial fibrillation, efficacy of stroke prevention with oral anticoagulant therapy has been proved. However, there are patients who are not candidates for long-term oral anticoagulation, namely patients with high risk of bleeding complications or previous hemorrhagic stroke. In those patients, percutaneous closure of left(More)
OBJECTIVES To investigate the effect of transcervical amnioinfusion on the management of labour and neonatal outcomes in preterm premature rupture of the membranes. STUDY DESIGN This clinical trial included 86 patients with premature rupture of the membranes between weeks 27 and 35 of gestation. Patients were randomly assigned to receive amnioinfusion via(More)
We report the clinical case of a clinical case of a 50-year-old woman who had a very rare complication related to the insertion of Kirschner wires for fixation of a left humerus fracture. Sixteen years after the placement of the Kirschner wires, a routine chest X-ray revealed that one of the Kirschner wires had migrated through the pleural cavity. Chest(More)