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  • Dominique Schols, Sofie Struyf, Jo Van Damme, José A. Esté, Geoffrey W. Henson, Erik De Clercq
  • Medicine, Biology
  • The Journal of experimental medicine
  • 1997 (First Publication: 20 October 1997)
  • Bicyclams are a novel class of antiviral compounds that are highly potent and selective inhibitors of the replication of HIV-1 and HIV-2. Surprisingly, however, when the prototype compound AMD3100Expand
  • Eduardo Pauls, Alba Ruiz, +15 authors José A. Esté
  • Medicine, Biology
  • The Journal of Immunology
  • 2014 (First Publication: 11 July 2014)
  • Proliferating cells are preferentially susceptible to infection by retroviruses. Sterile α motif and HD domain–containing protein-1 (SAMHD1) is a recently described deoxynucleotide phosphohydrolaseExpand
  • José A. Esté, Amalio Telenti
  • Medicine
  • The Lancet
  • 2007 (First Publication: 1 July 2007)
  • The need for new classes of antiretroviral drugs has become apparent because of increasing concern about the long-term toxic effects of existing drugs, the need to combat HIV-1 variants that areExpand
  • Laila Darwich, Gemma Roura Coma, +10 authors M. Bardají Bofill
  • Biology, Medicine
  • Immunology
  • 2009 (First Publication: 1 March 2009)
  • The interferon (IFN)-gamma component of the immune response plays an essential role in combating infectious and non-infectious diseases. Induction of IFN-gamma secretion by human T and natural killerExpand
  • Julià Blanco, Berta Bosch, María Teresa Fernández-Figueras, Jordi Barretina, Bonaventura Clotet, José A. Esté
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2004 (First Publication: 3 December 2004)
  • Cell-to-cell virus transmission is one of the most efficient mechanisms of human immunodeficiency virus (HIV) spread, requires CD4 and coreceptor expression in target cells, and may also lead toExpand