José A. Sepúlveda

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This paper presents a case study application of a cancer treatment center facility. A simulation model was created and integrated to a multi-objective optimization heuristic developed by the authors with the purpose of finding the best combination of control variables that optimize the performance of four different objectives related to the system. The(More)
This work addresses experience with a simulation model of a full service cancer treatment center. The objective was to analyze patient flow throughout the unit, evaluate the impact of alternative floor layouts, using different scheduling options and to analyze resources and patient flow requirements of a new building. The simulation model provided strong(More)
With the adoption of integration and system perspectives in managing the manufacturing systems and the pressure imposed by the increased competition and rapidly changing business environment, the need has arisen for new approaches for simulating the manufacturing enterprise. We have proposed SDDES; a hybrid System Dynamics Discrete Event Simulation approach(More)
Despite the size and importance of the health care industry, simulation is less prevalent in health care than in other fields such as manufacturing, logistics, and military applications. Yet simulation clearly has the potential to play a role in health care decision-making at many levels. The purpose of this panel is to discuss some of the issues that(More)
Certain business objectives cannot be met without the interaction and communication between different systems. An interesting concept called system of systems (SoS), which aims to describe this interaction between systems has been gaining attention in the last few years. In this paper an extensive review of the literature is performed to capture the main(More)
This study presents a new approach to solve multi-response simulation optimization problems. This approach integrates a simulation model with a genetic algorithm heuristic and a goal programming model. The genetic algorithm technique offers a very flexible and reliable tool able to search for a solution within a global context. This method was modified to(More)
This work presents a discrete event simulation model of an important sawmill in Chile. This model was used to perform a bottleneck analysis of the wood process and to propose, based on these results, alternatives that would yield to an improvement in the process productivity. Different alternatives were simulated and the results obtained were used to(More)
BACKGROUND Childhood asthma continues to be a growing medical concern in the United States, affecting > 17 million children in 1998. The mortality rate from asthma in children aged 5 to 14 years has nearly doubled, from 1.7 deaths per million to 3.2 deaths per million between 1980 and 1993. OBJECTIVE To evaluate the use of artificial neural networks(More)
The objective of this research is to develop a methodology which allows the user to validate the decisions of the man in the loop dynamically in real time by reducing type II errors. Case-based reasoning provides a modeling paradigm for designing a system which can aid in the validation process. This paradigm provides for a mechanism to capture cases that(More)
As the size and complexity of space launches continues to grow an architecture is becoming ever more necessary to accurately organize and determine workforce requirements for the involved organizations. The Launch Services Program at Kennedy Space Center has recently begun using a tool developed by the technology consulting firm Booz-Allen Hamilton(More)