José A. O. Simões

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Toscana virus infection is endemic in Italy, but has also been documented in other Mediterranean countries. Our aim was to investigate the occurrence of Toscana virus (TOSV) meningitis in children and young adults in a metropolitan area in the north of Portugal. Cerebrospinal fluid samples from 308 patients with the diagnosis of meningitis and with negative(More)
Total Knee Arthroplasty (TKA) changes mechanical loading of the knee joint. Bone loss in the tibia is commonly encountered at the time of the revision TKA. Restoration of lost bone support and joint stability are the primary challenges in revision TKA. Normally, these defects are treated with non-living structures like metallic augments or bone grafts(More)
Four finite element (FE) models of intact and distal femur of knee replacements were validated relative to measured bone strains. FE models of linear tetrahedrons were used. Femoral replacements with cemented stemless, cemented and noncemented femoral stems of the PFC Sigma Modular Knee System were analyzed. Bone strains were recorded at ten locations on(More)
OBJECTIVES The study of clinical features, diagnostic methods and prognostic factors of bacterial meningitis, in an urban area. PATIENTS AND METHODS All patients admitted between June 2001 and July 2004 in the emergency departments of a few hospitals, with the diagnosis of bacterial meningitis were included. CSF and blood cultures were performed in every(More)
A 3D finite element model of in vitro intact and implanted mandibles with different temporomandibular joints (TMJ) was analyzed. Three TMJ implant geometries were assessed. The displacements, stress and strain fields on the condyle were obtained for both simulated cases. Strains were also assessed near the screws that fixate the implant to the mandible. The(More)
Finite Element (FE) models for the simulation of intact and implanted bone find their main purpose in accurately reproducing the associated mechanical behavior. FE models can be used for preclinical testing of joint replacement implants, where some biomechanical aspects are difficult, if not possible, to simulate and investigate in vitro. To predict(More)
A programme has been established to characterize the long-term behaviour of cancellous bone. Fresh bovine cancellous specimens of dimensions 10 x 10 x 10 mm3 and 10 x 40 x 3.6 mm3 were manufactured and used within the testing programme. Results published in the literature indicate that the long-term behaviour of cancellous bone is well described by a power(More)
Bone mass distribution and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels. Mechanical stimulation of bone induces new bone formation in vivo and increases the metabolic activity and gene expression of osteoblasts in culture. A wide variety of devices have been tested for mechanical stimulation of cells and(More)
Twenty-two Serrana goats were studied through two successive estrous cycles in order to characterize their follicular dynamics during the breeding season. The ovaries of the goats were scanned daily by real-time ultrasonography and all follicles >or=3mm were measured and classified. The data were classified by the number of follicular waves per goat to test(More)
Restoration of lost bone support and joint stability are the primary challenges in revision total knee arthroplasty (TKA). Normally, the defects type 2B and type 3 are associated with several damaged metaphyseal bone and loss of cortical bone. Structural allografts have been used for the treatment of large, contained, or uncontained osseous defect in(More)