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Increased physical activity and decreased motivation to eat are common features in anorexia nervosa. We investigated the development of these features and the potential implication of brain-derived neurotrophic factor (BDNF) and dopaminergic signalling in their development in C57BL/6J and A/J inbred mice, using the 'activity-based anorexia' model. In this(More)
BACKGROUND Chemotherapy-induced nausea and vomiting (CINV) are major adverse effects of cancer chemotherapy. This study investigated: (1) the impact of CINV on patients' health-related quality of life (HRQL) in daily clinical practice; (2) the association between patient characteristics and type of antiemetics and CINV; and (3) the role of CINV in(More)
We investigated if nonnutritive sucking (NNS) during heelstick procedures alleviates behavioral distress in neonates. In our NICU, 26 neonates without severe complications (mean Minde score 0.8, range 0-3), undergoing heelstick procedures at least twice a day, in the first 2 weeks of life, were enrolled in the trial (mean gestational age 33.9 weeks, range(More)
Given a set V of points in the plane, a sequence d 0 ; d 1 ; : : : ; d k of non-negative numbers and an integer n, we are interested in the problem to assign integers from f0; : : : ; n?1g to the points in V such that if x;y 2 V are two points with euclidean distance less than d i , then the diierence between the labels of x and y is not equal to i. This(More)
OBJECTIVE The objective was to examine the added diagnostic value of on-site urine toxicology screening (UTS) in the routine assessment of psychiatric patients in an urban emergency setting. METHOD A naturalistic two-step prospective cohort study design was used enrolling all emergency room (ER) patients referred for psychiatric consultation. In two(More)
We present a 15-year-old girl and an 11-year-old boy who were prescribed dexamphetamine for treatment of Attention Deficit Hyperactivity Disorder (ADHD), and who subsequently presented with symptoms indicative of Cushing's syndrome. It turned out that both children had taken high doses of dexamethasone instead of dexamphetamine due to an error made by the(More)
In cooperation with the Rotterdam School of Management of the Erasmus University in Rotterdam, an expert system GUUS was developed in the intensive care unit of the Department of Thoracic Surgery of the Leiden University Hospital. This expert system is able to diagnose postoperative haemodynamic problems in patients after coronary artery surgery and can(More)
The birth of a neonate with congenital malformation for the parents determines often a process of adaptation with a phase of shock, a phase of incredibility and scare and, at last, one of adaptation and equilibration. The reactions of the parents and the difficulties they meet in the relation with the child depend mostly on the characteristics of the(More)
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