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The tetrodotoxin-resistant voltage-gated sodium channel (VGSC) Na(v)1.8 is expressed predominantly by damage-sensing primary afferent nerves and is important for the development and maintenance of persistent pain states. Here we demonstrate that muO-conotoxin MrVIB from Conus marmoreus displays substantial selectivity for Na(v)1.8 and inhibits pain behavior(More)
We present multi-color optical and two-frequency radio observations of the bright SAX event, GRB 990510. The well-sampled optical decay, and the radio observations are both inconsistent with simple spherical afterglow models. The achromatic optical steepening and the decay of the radio afterglow both occuring at t ∼ 1 day are evidence for hydrodynamical(More)
The omega-conotoxins from fish-hunting cone snails are potent inhibitors of voltage-gated calcium channels. The omega-conotoxins MVIIA and CVID are selective N-type calcium channel inhibitors with potential in the treatment of chronic pain. The beta and alpha(2)delta-1 auxiliary subunits influence the expression and characteristics of the alpha(1B) subunit(More)
The actions of external Cd2+ on the twitch and tetanic contractions, action potentials and potassium (K+) contractures of rat soleus muscle fibre bundles have been investigated. Cd2+ at 1-1.5 mM did not significantly alter tetanic tension, but increased twitch tension and increased the duration and overshoot of action potentials. At >/=3 mM, Cd2+ (1)(More)
  • V Pereyra, L Carcione, J Mould, R Freund
  • 2008
Large scale wave propagation simulation is currently achievable in reasonable turnaround times by using distributed computing in multiple cpu clusters. However, if one needs to perform many such simulations, as is the case in optimization, tomography, or seismic imaging, then the resources required are still prohibitive. Model order reduction of large(More)
Transient "Cd2+ withdrawal" contractures, with amplitudes of < or =60% peak tetanic tension, were seen when > or =3 mM Cd2+ was removed, after exposures lasting > or =5 min, from solutions bathing rat soleus fibres at 22 degrees C with Cl- as the major external anion. The minimum free [Cd2+] for withdrawal contractures was reduced twofold when the external(More)
The experiments examine the effects of membrane potential on the time course of K+ contractures in small bundles of rat soleus and extensor digitorum longus (EDL) muscle fibers. Control K+ contractures were induced by exposure to a 200 mmol/L K+ solution in polarized fibers with a resting membrane potential of -83 mV (3.5 mmol/L K+), while test contractures(More)
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