Jorge Tejedor

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Pre-mRNA splicing relies on the poorly understood dynamic interplay between >150 protein components of the spliceosome. The steps at which splicing can be regulated remain largely unknown. We systematically analyzed the effect of knocking down the components of the splicing machinery on alternative splicing events relevant for cell proliferation and(More)
The OLR1 gene encodes the oxidized low-density lipoprotein receptor (LOX-1), which is responsible for the cellular uptake of oxidized LDL (Ox-LDL), foam cell formation in atheroma plaques and atherosclerotic plaque rupture. Alternative splicing (AS) of OLR1 exon 5 generates two protein isoforms with antagonistic functions in Ox-LDL uptake. Previous work(More)
The safety of a railway network is a very important issue considered very labour-intensive. Authors have developed different approaches in order to detect automatically the safety for mid-small railway networks. Although these approaches are very simple to implement, they have the drawback of being unsuitable to large networks since the algorithm takes(More)
Alternative splicing of Fas/CD95 exon 6 generates either a membrane-bound receptor that promotes, or a soluble isoform that inhibits, apoptosis. Using an automatized genome-wide siRNA screening for alternative splicing regulators of endogenous transcripts in mammalian cells, we identified 200 genes whose knockdown modulates the ratio between Fas/CD95(More)
In this paper we introduce the idea of using a reliability measure associated to the predictions made by recommender systems based on collaborative filtering. This reliability measure is based on the usual notion that the more reliable a prediction, the less liable to be wrong. Here we will define a general reliability measure suitable for any arbitrary(More)
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