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Alzheimer disease is a progressive neurodegenerative brain disorder that leads to major debilitating cognitive deficits. It is believed that the alterations capable of causing brain circuitry dysfunctions have a slow onset and that the full blown disease may take several years to develop. Therefore, it is important to understand the early, asymptomatic, and(More)
The modeling of collaborative business processes is an important issue in order to allow enterprises to implement B2B collaborations with their business partners. We have proposed an MDA-based methodology for the modeling, verification and implementation of collaborative processes. Since collaborative process models are the main artifacts in this MDA-based(More)
Hyperalgesia and allodynia occur as a consequence of peripheral and central sensitization that follows sustained nociceptive activation. The cellular alterations associated to this state of nociceptive network hyperexcitability represent a form of neuronal plasticity, but they are not well understood because of its complexity in situ. In this study, after(More)
Previous studies, using electrophysiological and fluorimetric analysis with a calcium sensitive dye, have shown that 5-7 DIV developing spinal cord neurons displayed high levels of glycinergic transmission. GABAergic and AMPAergic neurotransmission contributed much less to the overall transmission. Here, we show that culturing neurons in absence of a glia(More)
It is believed that amyloid-β peptide (Aβ), in its aggregated-oligomeric state, constitutes one of the neurotoxic factors involved in the pathogenesis of Alzheimer's disease. With the objective of studying a potential role of the peptide on synaptic transmission, we studied the effect of soluble Aβ(1-40) on synaptic transmission in rat hippocampal neurons.(More)
The design and implementation of collaborative business processes and the Business-to-Business (B2B) systems that support them is an important issue in order to enable enterprises to set up B2B collaborations. This involves new challenges, mainly regarding the ability to cope with change, decentralized management, peer-to-peer interactions, preservation of(More)
In Artificial Intelligence courses, the development of intelligent agents is a common practical work. However, it is a programming extensive and consumed time practice that much of the time the student cannot solve in full and in time. In this work the authors present FAIA, a framework to develop intelligent agents giving a partially design solution. With(More)