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PET of brain amyloid and tau in mild cognitive impairment.

• Gary W. Small, Vladimir Kepe, +12 authors Jorge R. Barrio
• The New England journal of medicine
• 2006

BACKGROUND Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of Alzheimer's disease that accumulate in the cortical regions of the brain in persons with mild… (More)

Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease.

• Kooresh Shoghi-Jadid, Gary W. Small, +8 authors Jorge R. Barrio
• The American journal of geriatric psychiatry…
• 2002

The authors used 2-(1-(6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naphthyl)ethylidene)malononitrile ([18F]FDDNP), a hydrophobic radiofluorinated derivative of… (More)

Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET.

• Randall A. Hawkins, Younggeun Choi, +6 authors Michael E. Phelps
• Journal of nuclear medicine : official…
• 1992

To evaluate the feasibility of quantitatively assessing regional skeletal fluoride uptake in humans in focal and generalized bone disease, we investigated the skeletal kinetics of [18F]fluoride ion… (More)

Quantifying local cerebral blood flow by N-isopropyl-p-[123I]iodoamphetamine (IMP) tomography.

• David E. Kuhl, Jorge R. Barrio, +6 authors Michael E. Phelps
• Journal of nuclear medicine : official…
• 1982

A model was validated wherein local cerebral blood flow (LCBF) in humans was quantified by single-photon emission computed tomography (SPECT) with intravenously injected… (More)

Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease.

• Eric D. Agdeppa, Vladimir Kepe, +7 authors Jorge R. Barrio
• The Journal of neuroscience : the official…
• 2001

Senile plaques (SPs) and neurofibrillary tangles (NFTs) are hallmark pathologies accompanying the neurodegeneration involved in Alzheimer's disease (AD), for which beta-amyloid (Abeta) peptide is a… (More)

Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography.

• Sanjiv Sam Gambhir, Jorge R. Barrio, +11 authors Harvey R. Herschman
• Proceedings of the National Academy of Sciences…
• 1999

We are developing quantitative assays to repeatedly and noninvasively image expression of reporter genes in living animals, using positron emission tomography (PET). We synthesized positron-emitting… (More)

Imaging transgene expression with radionuclide imaging technologies.

• Sanjiv Sam Gambhir, Harvey R. Herschman, +10 authors Ronald A Blasberg
• Neoplasia
• 2000

A variety of imaging technologies are being investigated as tools for studying gene expression in living subjects. Noninvasive, repetitive and quantitative imaging of gene expression will help both… (More)

A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography.

• Sanjiv Sam Gambhir, Eileen M. Bauer, +7 authors Harvey R. Herschman
• Proceedings of the National Academy of Sciences…
• 2000

We are developing assays for noninvasive, quantitative imaging of reporter genes with positron emission tomography (PET), for application both in animal models and in human gene therapy. We report… (More)

Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir.

• Sanjiv Sam Gambhir, Jorge R. Barrio, +13 authors Harvey R. Herschman
• Journal of nuclear medicine : official…
• 1998

UNLABELLED We are developing procedures to repeatedly and noninvasively image the expression of transplanted reporter genes in living animals and in patients, using PET. We have investigated the use… (More)

Molecular imaging of lymphoid organs and immune activation using positron emission tomography with a new 18F-labeled 2′-deoxycytidine analog

• Caius G Radu, Chengyi Jenny Shu, +5 authors Owen N Witte
• Nature Medicine
• 2008

Monitoring immune function with molecular imaging could have a considerable impact on the diagnosis and treatment evaluation of immunological disorders and therapeutic immune responses. Positron… (More)

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