Jorge Luis Cervantes

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The endosomal Toll-like receptors (TLRs) TLR3, TLR7, TLR8 and TLR9 are important in sensing foreign nucleic acids encountered by phagocytes. Because TLR8 was initially thought to be non-functional in mice, less is known about TLR8 than the genetically and functionally related TLR7. Originally associated with the recognition of single-stranded RNA of viral(More)
Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole(More)
BACKGROUND The clinical syndrome associated with secondary syphilis (SS) reflects the propensity of Treponema pallidum (Tp) to escape immune recognition while simultaneously inducing inflammation. METHODS To better understand the duality of immune evasion and immune recognition in human syphilis, herein we used a combination of flow cytometry,(More)
The Acknowledgements section in this Article is incomplete. " We thank Drs. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under(More)
MyD88 adaptor protein mediates numerous biologically important signal transduction pathways in innate immunity. MyD88 signaling fosters bacterial containment and is necessary to raise an adequate innate and acquired immune response to Mycobacterium tuberculosis (Mtb). The phagosome is a crucial cellular location not only for Mtb replication, but it is also(More)
The nuclear pregnane X receptor (PXR) plays a central role in regulating xenobiotic metabolism. We now report a novel role for PXR as a critical negative regulator of innate immunity after infection. Pxr(-/-) mice exhibited remarkably elevated pro-inflammatory cytokine and chemokine production following infection with Listeria monocytogenes (Lm). Despite(More)
Resumen Se describe el caso de un lactante masculino de 3 meses, con asociación de tetralogía de Fallot y conexión anómala total de venas pul-monares, diagnosticada por ecocardiografía y en quien se realizó corrección completa de su cardiopatía con buenos resultados. We report the case of an infant 3 months old with a rare association, tetralogy of Fallot(More)
Exclusión del ventrículo venoso. Evolución y retos. A propósito de los primeros cien casos del procedimiento de Fontan en el Instituto Nacional de Cardiología " Ignacio Chávez " Summary EXCLUSION OF VENOUS VENTRICLE. The history and evolution of the cardiovascular surgery and pediatric cardiology is fascinating. For centuries many erroneous galenic concepts(More)
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