Jorge López Moreno

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Prion diseases are rare neurodegenerative conditions associated with the conformational conversion of the cellular prion protein (PrP(C)) into PrP(Sc), a self-replicating isoform (prion) that accumulates in the central nervous system of affected individuals. The structure of PrP(Sc) is poorly defined, and likely to be heterogeneous, as suggested by the(More)
Serious Games are specifically designed to develop mental abilities and skills such as strategy, mental calculation and decision making but the acquisition of deep knowledge with Serious Games is less well understood. To improve this understanding, a game called TimeMesh, as well as the needed graphic engine, called TimeMesh engine, -a multi-player(More)
Prion diseases or Transmissible Spongiform Encephalopathies (TSEs) are a group of fatal neurodegenerative disorders affecting several mammalian species. Its causative agent, disease-associated prion protein (PrPd), is a self-propagating β-sheet rich aberrant conformation of the cellular prion protein (PrPC) with neurotoxic and aggregation-prone properties,(More)
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