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Prevention of Synaptic Alterations and Neurotoxic Effects of PAMAM Dendrimers by Surface Functionalization
One of the most studied nanocarriers for drug delivery are polyamidoamine (PAMAM) dendrimers. However, the alterations produced by PAMAM dendrimers in neuronal function have not been thoroughlyExpand
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Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors.
Glycine receptors (GlyRs) are members of the pentameric ligand-gated ionic channel family (pLGICs) and mediate fast inhibitory neurotransmission in the brain stem and spinal cord. The function ofExpand
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Neurotoxin-like compounds from the ichthyotoxic red tide alga Heterosigma akashiwo induce a TTX-like synaptic silencing in mammalian neurons
Abstract Heterosigma akashiwo (Raphidophyceae) is a golden-brown unicellular marine microalgae that has been implicated in massive numbers of fish deaths in natural and cultured populations aroundExpand
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Inhibitory Actions of Tropeines on the α3 Glycine Receptor Function
Glycine receptors (GlyRs) are chloride-permeable pentameric ligand-gated ion channels. The inhibitory activity of GlyRs is essential for many physiological processes, such as motor control andExpand