Jorge Augusto Borin Scutti

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Malignant melanoma is one the most aggressive types of cancer and its incidence has gradually increased in the last years, accounting for about 75% of skin cancer deaths. This poor prognosis results from the tumor resistance to conventional drugs mainly by deregulation of apoptotic pathways. The aim of this work was to investigate the cell death mechanism(More)
Melanoma is the most aggressive form of skin cancer, and its incidence has increased dramatically over the years. The murine B16F10 melanoma in syngeneic C57Bl/6 mice has been used as a highly aggressive model to investigate tumor development. Presently, we demonstrate in the B16F10-Nex2 subclone that silencing of SOCS-1, a negative regulator of Jak/Stat(More)
A plenty of studies have investigated the immune system of cancer patients and they suffer from a large immunosuppression mainly due to decrease of lymphocyte proliferation and cytotoxic activity. Several efforts have been made in developing drugs or strategies to improve the treatment of cancer patients. Cancer immunotherapy is one of the best strategy to(More)
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