Jorge Aranda

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Every bug has a story behind it. The people that discover and resolve it need to coordinate, to get information from documents, tools, or other people, and to navigate through issues of accountability, ownership, and organizational structure. This paper reports on a field study of coordination activities around bug fixing that used a combination of case(More)
Small companies form a large part of the software industry, but have mostly been overlooked by the requirements engineering research community. We know very little about the techniques these companies use to elicit and track requirements and about their contexts of operations. This paper presents preliminary results from an ongoing exploratory case study of(More)
The use of viewpoints has long been proposed as a technique to structure evolving requirements models. In theory, viewpoints should provide better stakeholder traceability, and the ability to discover important requirements by comparing viewpoints. However, this theory has never been tested empirically. This paper reports on an exploratory case study of a(More)
If designers of modelling languages want their creations to be used in real software projects, the communication qualities of their languages need to be evaluated, and their proposals must evolve as a result of these evaluations. A key quality of communication artifacts is their comprehensibility. We present a flexible framework to evaluate the(More)
Replications play an important role in verifying empirical results. In this paper, we discuss our experiences performing a literal replication of a human subjects experiment that examined the relationship between a simple test for consistent use of mental models, and success in an introductory programming course. We encountered many difficulties in(More)
A considerable amount of research has been dedicated to bring the vision of model-driven engineering (MDE) to fruition. However, the practical experiences of organizations that transition to MDE are underreported. This paper presents a case study of the organizational consequences experienced by one large organization after transitioning to MDE. We present(More)
Vasoinhibins are a family of peptides derived from prolactin, growth hormone and placental lactogen that act on endothelial cells to suppress vasodilation and angiogenesis and to promote apoptosis-mediated vascular regression. Some of the pathways by which vasoinhibins act have now been defined, and recent developments indicate that endogenous vasoinhibins(More)
Vasoconstriction and defective placental angiogenesis are key factors in the etiology of preeclampsia. Prolactin levels are elevated in maternal blood throughout pregnancy and the human decidua produces prolactin that is transported to the amniotic fluid. Prolactin is cleaved to yield vasoinhibins, a family of peptides that inhibit angiogenesis and nitric(More)
Oral intake of Microcystin-LR (MC-LR) is the principal route of exposure to this toxin, with prolonged exposure leading to liver damage of unspecific symptomatology. The aim of the present paper was therefore to investigate the liver and intestine damage generated by prolonged oral exposure to low MC-LR doses (50 and 100 μg MC-LR/kg body weight,(More)