Jorge Albareda

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Mesenchymal stem cells (MSCs) are being investigated for the treatment of equine joint diseases because of their regenerative potential. Recently, the focus mainly has addressed to their immunomodulatory capacities. Inflammation plays a central role in joint pathologies, since the release of proinflammatory mediators to the synovial fluid (SF) leads to the(More)
Mesenchymal stem cells (MSCs) are gaining relevance for treating equine joint injuries because of their ability to limit inflammation and stimulate regeneration. Because inflammation activates MSC immunoregulatory function, proinflammatory priming could improve MSC efficacy. However, inflammatory molecules present in synovial fluid or added to the culture(More)
This paper presents a modeling methodology for clinical guidelines used in hospitals. The clinical guidelines are assumed to be given in a graphical form in a structure obtained by combining few elements. It is shown how the clinical guidelines represented with this syntax can be automatically converted into a mathematical model represented as Petri nets.(More)
Mesenchymal stem cells (MSCs) have a great potential for treating equine musculoskeletal injuries. Although their mechanisms of action are not completely known, their immunomodulatory properties appear to be key in their functions. The expression of immunoregulatory molecules by MSCs is regulated by proinflammatory cytokines; so inflammatory priming of MSCs(More)
HEAT (Healthcare Efficiency and Effectiveness Analysis Tool) is a software application developed to support designing and analysis processes of the clinical pathways. It was developed in collaboration with the Hospital “Lozano Blesa” in Zaragoza, and is composed by two different tools. The first one, called HEAT-Scenario Designer, can be used(More)
This paper considers the operation scheduling and planning of elective patients in the Orthopedic Department of the “Lozano Blesa” Hospital in Zaragoza. We assume an ordered list of patients that should be planned for surgery in two available rooms, each room being possible to be used for a specific duration per day. Based on the average(More)
Curettage and filling with acrylic cement in the treatment of para-articular giant cell tumor (GCT) has multiple advantages as compared to other methods; nonetheless, the possibility of progression in arthrosis is still a drawback. The literature does not report long-term functional results when this method was used. Four cases are presented with a mean(More)
OBJECTIVE To study the causes and outcomes of patients with interprosthetic femoral fractures. MATERIAL AND METHODS A retrospective review conducted on 7 patients treated between 2010 and 2013. The knee arthroplasties had been implanted for at least 5 years, and those of the hip less than a year. They were bipolar cemented in 6 patients and totally(More)
BACKGROUND Mesenchymal stem cells (MSCs) transplantation has become a promising therapeutic choice for musculoskeletal injuries. Joint-related disorders are highly prevalent in horses. Therefore, these animals are considered as suitable models for testing MSC-based therapies for these diseases. The aim of this study was to investigate the clinical and(More)
INTRODUCTION Trochanteric hip fractures in elderly patients with osteoporosis are commonly caused by low energy trauma. The cardioversion therapy is an extremely rare cause of this type of fracture. PRESENTATION OF CASE We report the case of a woman with hip fracture after cardioversion. DISCUSSION We discuss the production mechanism of this injury and(More)