Jorge A. Suarez

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Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50-65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death(More)
Fish meal (FM) has long been considered an essential ingredient for the formulation of shrimp feeds. Until recently, 12%FM was considered a minimum amount, below which weight gain would become reduced due to a reduction in feed intake. In order to test this perceived minimum value, an experiment was conducted on a long-term basis with 4 replicates. Four(More)
Many of the effects of dietary restriction (DR) on longevity and health span in model organisms have been linked to reduced protein and amino acid (AA) intake and the stimulation of specific nutrient signaling pathways. Studies in yeast have shown that addition of serine, threonine, and valine in media promotes cellular sensitization and aging by activating(More)
Dietary interventions have not been effective in the treatment of multiple sclerosis (MS). Here, we show that periodic 3-day cycles of a fasting mimicking diet (FMD) are effective in ameliorating demyelination and symptoms in a murine experimental autoimmune encephalomyelitis (EAE) model. The FMD reduced clinical severity in all mice and completely reversed(More)
of a thesis at the University of Miami. Thesis supervised by Professor Daniel D. Benetti. No. of pages in text. (38) Efforts to reduce the use of fishmeal in aquafeeds for carnivorous marine fish have been a focal point of aquaculture nutrition research in recent years. Building upon such research, this study was designed to compare the digestibility,(More)
Female C3H/He mice carrying the mammary tumor virus (MTV) were monitored for mammary tumor incidence and latent periods while submitted to a daily subcutaneous injection with amphetamine (0,4 mg/kg/day). Results show that amphetamine caused an increase in incidence and a decrease in latency of tumors compared with placebo. There was also appreciated a(More)
Several experiments were conducted to evaluate the effects of chronic amphetamine on the influenza A (PR-8/34) virus specific immune injury in CD-1 mice. Treatment with amphetamine resulted in a significant increase of lung virus titers and pulmonary vascular permeability. Amphetamine also increased the lethality of infected mice.
Funding information Gulf of Mexico Research Initiative, Grant/ Award Number: SA1520; Relationship of Effects of Cardiac Outcomes in fish for Validation of Ecological Risk Abstract Mahi-mahi Coryphaena hippurus is a promising species for aquaculture development and has been used as a model species for oil toxicology and physiology studies. This species has(More)
Epinephelus morio is a large carnivorous species of the Caribbean Sea under reproduction in captivity and nutritional physiology. A diet with raw cornstarch (RCS) was compared to a basal diet without starch (basal) to measure plasma glucose, liver glycogen, and intermediary metabolism. Glucose level did not change (p > 0.05) whereas liver glycogen was(More)