Fabiana Santana3
Ana P Crestani3
Lindsey F Cassini3
Rodrigo O Sierra3
Johanna M Duran2
3Fabiana Santana
3Ana P Crestani
3Lindsey F Cassini
3Rodrigo O Sierra
2Johanna M Duran
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CB1 cannabinoid receptors are abundantly expressed in the brain, with large concentrations present in the hippocampus, a brain structure essential for memory processing. In the present study, we have investigated the possible modulatory role of the endocannabinoid system in the dorsal hippocampus upon the different phases of memory processing of an aversive(More)
  • Alessandra Swarowsky, Letícia Rodrigues, Regina Biasibetti, Marina C Leite, Lucas Fürstenau de Oliveira, Lucia M V de Almeida +4 others
  • 2008
Lesion of the nucleus basalis magnocellularis (nbm) is a suitable approach to study cognitive deficit and behavior alterations involving cholinergic dysfunction, which is associated with the major types of dementia. Cortical astrogliosis also has been described in this model, but it is not clear whether hippocampal astrocytes are activated. In this study,(More)
  • Lindsey F Cassini, Rodrigo O Sierra, Josué Haubrich, Ana P Crestani, Fabiana Santana, Lucas de Oliveira Alvares +1 other
  • 2013
Motivated by the synaptic tagging and capture (STC) hypothesis, it was recently shown that a weak learning, only able to produce short-term memory (STM), can succeed in establishing long-term memory (LTM) with a concomitant, stronger experience. This is consistent with the capture, by the first-tagged event, of the so-called plasticity-related proteins(More)
  • Luisa A. Diehl, Lucas O. Alvares, Cristie Noschang, Douglas Engelke, Ana C. Andreazza, Carlos Alberto S. Gonçalves +2 others
  • 2011
Adverse early life events, such as periodic maternal separation, may alter the normal pattern of brain development and subsequently the vulnerability to a variety of mental disorders in adulthood. Patients with a history of early adversities show higher frequency of post-traumatic stress disorder (PTSD). This study was undertaken to verify if repeated(More)
The capacity to adapt to new situations is one of the most important features of memory. When retrieved, memories may undergo a labile state that is sensitive to modification. This process, called reconsolidation, can lead to memory updating through the integration of new information into a previously consolidated memory background. Thus reconsolidation(More)
Some memories enter into a labile state after retrieval, requiring reconsolidation in order to persist. One functional role of memory reconsolidation is the updating of existing memories. There are reports suggesting that reconsolidation can be modulated by a particular endogenous process taking place concomitantly to its natural course, such as water or(More)
The five muscarinic acetylcholine receptors (M(1)-M(5)) are differentially expressed in the brain. M(2) and M(4) are coupled to inhibition of stimulated adenylyl cyclase, while M(1), M(3) and M(5) are mainly coupled to the phosphoinositide pathway. We studied the muscarinic receptor regulation of adenylyl cyclase activity in the rat hippocampus, compared to(More)
Muscarinic receptors in the hippocampus are relevant to learning and memory, but the role of each subtype is poorly understood. Muscarinic toxins (MTs) from Dendroaspis snakes venom are selective for muscarinic receptor subtypes. MT2, a selective agonist for M(1) receptors, given into the hippocampus immediately after training, improved memory consolidation(More)
The muscarinic cholinergic receptor (MAChR) blockade with scopolamine either extended or restricted to the hippocampus, before or after training in inhibitory avoidance (IA) caused anterograde or retrograde amnesia, respectively, in the rat, because there was no long-term memory (LTM) expression. Adult Wistar rats previously exposed to one or two open-field(More)
Muscarinic Cholinergic receptors of the subtype M4 are G protein coupled receptors that activate Gi reducing AMPc concentration on the cell and closing K + channels , causing hyperpolarization of the cell membrane and reduction of neurotransmitter release [1]. Previous works from our laboratory using the very selective Mus-carinic Toxin 3 (MT3) to block M4(More)