Jorge A Negroni

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The effect of mechano-electric feedback (MEF) on myocyte's action potential (AP) has been largely studied considering constant stretches. The present study examined the role of MEF utilizing a model built by integrating mathematical descriptions of cardiac myocyte's electrical activity, contraction and MEF. This model simulates the four phases of the(More)
We have recently reported that in chronic myocardial ischemia, adult mammalian cardiomyocytes express P-glycoprotein (P-gp). We now investigate if P-gp is also expressed in acute regional ischemia followed by reperfusion. Adult conscious sheep underwent 12-min occlusion of the mid-left anterior descending artery (inflatable cuff). Successful(More)
See article by Papp et al. [10] (pages 396–405) in this issue. Ischemic preconditioning is a natural mechanism by which brief periods of ischemia–reperfusion initiate a complex cascade of events that culminate in the protection of the heart against a subsequent sustained ischemia, reducing infarct size, postischemic dysfunction, and the incidence of(More)
The performance in one trial passive avoidance learning and the degree of activity were determined in adulthood, from neonatal hormone treated and intact rats. Activity was measured in the same environmental conditions in which the learning test takes place, i.e., shuttle box unequally illuminated. The treated groups were androgenized females and castrated(More)
The degree of activity and the performance in active avoidance learning were determined in adulthood, from neonatal hormone treated and intact rats. The treated groups were androgenized females and castrated males and females. Normal males and females composed the intact groups. Activity was measured in two tests situations, i.e., open field and shuttle(More)
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