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Animals exposed to 3,3'-iminodipropionitrile (IDPN) or to several similar nitriles develop a permanent syndrome of behavioral abnormalities. The present work addressed the hypothesis that this syndrome is caused by a toxic effect of these nitriles on the peripheral vestibular system. Male Long-Evans rats were given acute doses of IDPN (0, 200, 400, 600, or(More)
The effects of subchronic 3,3'-iminodipropionitrile (IDPN) were characterized in the adult Long-Evans male rat. In a preparatory experiment, acute IDPN (890 mg/kg, IP) and intratympanic arsanilic acid caused similar alterations in locomotor activity, rearings, and scores for vestibular impairment. In a second preparatory experiment, IDPN in the drinking(More)
Animals exposed to allylnitrile develop permanent abnormalities in motor behaviour, similar to those caused by 3,3'-iminodipropionitrile (IDPN) and crotononitrile. IDPN and crotononitrile effects have been attributed to vestibular hair cell degeneration, but allylnitrile has been suggested to modify behaviour through neuronal degeneration in the CNS. Adult(More)
A variety of stimuli cause sensory hair cell loss in the mammalian inner ear. This loss occurs by several differing processes, the significance of which remains undetermined. This study examines the relationship between the intensity of the damaging stimulus and the mode of hair cell loss found in the vestibular sensory epithelia of the rat. The ototoxin(More)
Exposure of rats to 3,3'-iminodipropionitrile (IDPN) results in neurofilament (NF)-filled swellings in the proximal axons of a number of large neurons, including sensory neurons in the dorsal root ganglia (DRG) and motor neurons in the spinal cord. The present report describes the effects of acute and chronic IDPN exposure on the vestibular ganglion (VG)(More)
The inferior olive climbing fibre projection is key to cerebellar contributions to motor control. Here we present evidence for a novel tool, trans-crotononitrile (TCN), to selectively inactivate the olive to study its functions. Anatomical, electrophysiological and behavioural techniques have been used in rats to assess the CNS effects of TCN, with a focus(More)
The present work was aimed at characterizing, using both scanning- and transmission-electron microscopy, the morphological changes occurring in the vestibular sensory epithelia of rats exposed to the synthetic nitrile 3,3'-iminodipropionitrile (IDPN), that belongs to a new class of vestibulotoxic compounds. Male Long-Evans rats were administered 0, 200,(More)
The use of electronic devices for canopy characterization has recently been widely discussed. Among such devices, LiDAR sensors appear to be the most accurate and precise. Information obtained with LiDAR sensors during reading while driving a tractor along a crop row can be managed and transformed into canopy density maps by evaluating the frequency of(More)
The dinitrile compound 3,3'-iminodipropionitrile causes a number of toxic effects in sensory systems, including degeneration of the vestibular sensory hair cells, as well as a neurofilamentous pathology in motor and sensory neurons. The chemical also causes permanent changes in behavior. These were initially attributed to the effect on neurofilaments, but(More)
Guanylate cyclase activating proteins are EF-hand containing proteins that confer calcium sensitivity to retinal guanylate cyclase at the outer segment discs of photoreceptor cells. By making the rate of cGMP synthesis dependent on the free intracellular calcium levels set by illumination, GCAPs play a fundamental role in the recovery of the light response(More)