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Abnormalities of Neuronal Oscillations and Temporal Integration to Low- and High-Frequency Auditory Stimulation in Schizophrenia
TLDR
The SZ auditory cortices were unable to generate healthy levels of theta and high gamma band (80-Hz) entrainment (aSSR) and augment transient responses (M100s) to rapidly presented auditory information (an index of temporal integration). Expand
Endogenous Sequential Cortical Activity Evoked by Visual Stimuli
TLDR
It is demonstrated that visual stimuli recruit similar sequential patterns to the ones observed spontaneously, consistent with the hypothesis that already existing Hebbian cell assemblies firing in predefined temporal sequences could be the microcircuit substrate that encodes visual percepts changing in time. Expand
Somatostatin Interneurons Control a Key Component of Mismatch Negativity in Mouse Visual Cortex.
TLDR
Using fast two-photon calcium imaging and multielectrode recordings in awake mice, it is found that visual cortical circuits display adapted (decreased) responses to repeated stimuli and amplified responses to a deviant stimulus, the key component of human MMN. Expand
Reliable and Elastic Propagation of Cortical Seizures In Vivo.
TLDR
An epilepsy circuit model resembling an elastic meshwork is proposed, wherein ictal progression faithfully follows preexistent pathways but varies flexibly in time, depending on the local inhibitory restraint. Expand
Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers.
TLDR
These data illustrate how multiple pathways may lead to clinically similar psychosis manifestations, and they provide explanations for the marked heterogeneity observed across laboratories on the same biomarker variables when DSM diagnoses are used as the gold standard. Expand
Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers.
(Reprinted with permission from American Journal of Psychiatry 2016; 173:373-384).
Augmented gamma band auditory steady-state responses: Support for NMDA hypofunction in schizophrenia
TLDR
Results indicate that SZ have augmented aSSRs that were most extreme in the gamma range, and report a novel pattern of aSSR abnormalities suggesting that gamma band neural entrainment deviations among SZ may be more complex than previously supposed, including possibly being substantially influenced by physical stimulus properties. Expand
Preparatory Activations across a Distributed Cortical Network Determine Production of Express Saccades in Humans
TLDR
A post hoc path analysis suggested that the observed cortical activations leading to express saccades are best understood as an interdependent chain of events that affect express sAccade production, highlighting the importance of a distributed posterior cortical network, particularly in right hemisphere, that prepares the saccade system for rapid responding. Expand
Altered Cortical Ensembles in Mouse Models of Schizophrenia
TLDR
Results are consistent with the hypothesis that schizophrenia is an "attractor" disease and demonstrate that degraded neuronal ensembles are a common consequence of diverse genetic, cellular, and synaptic alterations seen in chronic schizophrenia. Expand
Event-Related Potential and Time-Frequency Endophenotypes for Schizophrenia and Psychotic Bipolar Disorder
TLDR
This study supports for both shared and unique deficits in early sensory and late cognitive processing across psychotic diagnostic groups and provides insight into deficits in underlying neural architecture and potential protective/compensatory mechanisms in unaffected relatives. Expand
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