Jordan A. Doumanov

Learn More
Autosomal-recessive retinitis pigmentosa (arRP) was recently associated with mutations in a novel gene EYS, spanning over 2 Mb, making it the largest known gene expressed in the human eye. The purpose of this study was to establish the prevalence and nature of EYS mutations in a clinically well-characterized cohort of 239 sporadic and arRP French cases.(More)
Interleukin-6-type cytokine receptors are expressed in polarized cells such as hepatocytes and intestinal cells. For the interleukin-6-receptor gp80 and its signal transducer gp130, a preferential basolateral localization was demonstrated in Madin-Darby canine kidney (MDCK) cells and two basolateral sorting signals were identified within the cytoplasmic(More)
Mutations in BEST1 gene, encoding the bestrophin-1 (Best1) protein are associated with macular dystrophies. Best1 is predominantly expressed in the retinal pigment epithelium (RPE), and is inserted in its basolateral membrane. We investigated the cellular localization in polarized MDCKII cells of disease-associated Best1 mutant proteins to study specific(More)
Snake venom Phospholipases A2 (svPLA2) are among the main toxic venom components with a great impact on different tissues and organs based on their catalytic specificity and a variety of pharmacological effects, whose mechanism is still under debate. The main toxic component, isolated from the venom of Vipera ammodytes meridionalis, is the heterodimeric(More)
Secreted Phospholipases A2 (sPLA2s) represent a large family of structurally related enzymes, which target different tissues and organs and induce numerous pharmacological effects based on their catalytic specificity hydrolysis of the sn-2 ester bond of glycerophospholipids. The neurotoxin vipoxin, isolated from the venom of Vipera ammodytes meriodionalis,(More)
Changes in the functional characteristics of tumor and normal cells after treatment with extracts of white dead-nettle Ralitsa Veleva, Bela Petkova, Veselina Moskova-Doumanova, Jordan Doumanov, Milena Dimitrova, Petya Koleva, Kirilka Mladenova, Svetla Petrova, Zhenya Yordanova, Veneta Kapchina-Toteva and Tanya Topouzova-Hristova* Department of Cytology,(More)
Transepithelial resistance in human bestrophin-1 stably transfected Madin Darby canine kidney cells Kirilka Mladenova, Svetla Petrova, Veselina Moskova-Doumanova, Tanya Topouzova-Hristova, Stoyanka Stoitsova, Irena Tabashka, Christina Chakarova, Zdravko Lalchev and Jordan Doumanov* Faculty of Biology, Sofia University “St. Kliment Ohridski”, Sofia,(More)
Human bestrophin-1 (hBest1) is a transmembrane calcium-activated chloride channel protein - member of the bestrophin family of anion channels, predominantly expressed in the membrane of retinal pigment epithelium (RPE) cells. Mutations in the protein cause ocular diseases, named Bestrophinopathies. Here, we present the first Fourier transform infrared(More)
The aim of the present study was to estimate the lung surfactant maturity by analyses of gastral aspirates (GA) from prematurely born and full-term infants. A biochemical analysis of the protein and lipid content in GA from the children groups tested was made. By thin-layer chromatography the individual phospholipids components in GA samples from(More)