Joong-Hyun Kim

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Magnetic nanofibrous scaffolds of poly(caprolactone) (PCL) incorporating magnetic nanoparticles (MNP) were produced, and their effects on physico-chemical, mechanical and biological properties were extensively addressed to find efficacy for bone regeneration purpose. MNPs 12 nm in diameter were citrated and evenly distributed in PCL solutions up to 20% and(More)
Alveolar bone regeneration is a significant challenge in dental implantation. Novel biomaterials and tissue-engineered constructs are under extensive development and awaiting in vivo animal tests to find clinical endpoint. Here, we establish a novel in vivo model, modifying gingivoperiosteoplasty in rat for the alveolar bone regeneration. Rat premaxillary(More)
The development of optimized biomaterials for restoring bone defects has been ongoing for many years. Animal models for testing bone grafts and tissue engineered constructs are an important aspect of this research. New bone scaffolding systems need to be tested both in vitro and in vivo, but ultimately animal studies provide answers and confidence in their(More)
Complete reconstruction of damaged periodontal pockets, particularly regeneration of periodontal ligament (PDL) has been a significant challenge in dentistry. Tissue engineering approach utilizing PDL stem cells and scaffolding matrices offers great opportunity to this, and applying physical and mechanical cues mimicking native tissue conditions are of(More)
Vascularization is a key issue for the success of tissue engineering to repair damaged tissue. In this study, we report a composite scaffold delivering angiogenic factor for this purpose. Vascular endothelial growth factor (VEGF) was loaded on mesoporous silica nanoparticle (MSN), which was then incorporated within a type I collagen sponge, to produce(More)
Periodontitis is one of the most common bacterial and infectious diseases characterized by deepening of the periodontal pockets and loss of attachment, and tooth loss. Periodontitis is associated with high levels of various pro-inflammatory mediators, which result in extensive destruction of connective and bone tissues. The aim of this study was to(More)
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