Joon Yup Kim

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A recombinant adenovirus (AdVAFP1-IL2) containing the murine alpha-fetoprotein (AFP) promoter was constructed to direct hepatocellular carcinoma (HCC)-specific expression of the human interleukin-2 (IL-2) gene. In vitro testing of AdVAFP1-IL2 showed HCC-specific IL-2 gene expression three to four orders of magnitude higher in AFP-producing HCC lines(More)
Rare stochastic mutations may accumulate during dormancy of stem-like cells, but technical limitations in DNA sequencing have limited exploring this possibility. In this study, we employed a recently established deep-sequencing method termed Duplex Sequencing to conduct a genome-wide analysis of mitochondrial (mt) DNA mutations in a human breast stem cell(More)
1 Rare stochastic mutations may accumulate during dormancy of stem-like cells, but technical 2 limitations in DNA sequencing have limited exploring this possibility. In this study, we 3 employed a recently established deep sequencing method termed Duplex Sequencing to conduct 4 a genome-wide analysis of mitochondrial (mt) DNA mutations in a human breast(More)
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