Joon Young Jang

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OBJECTIVE To examine the effects of intravesical cyclooxygenase-2 (COX-2) inhibitors on the expression of inducible nitric oxide synthase (iNOS) and nerve growth factor (NGF) in cyclophosphamide (CYP)-induced overactive bladder (OAB). MATERIALS AND METHODS In all, 40 Sprague-Dawley rats were divided into control, OAB, and COX-2 inhibitor-treated groups.(More)
BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary kidney diseases that frequently result in renal failure. In this cross-sectional observational cohort study, we evaluated urinary angiotensinogen (AGT) as a potential biomarker to assess renal function in ADPKD. METHODS Urinary AGT was measured in 233(More)
BACKGROUND The role of hyperuricemia in disease progression of autosomal dominant polycystic kidney disease (ADPKD) has not been defined well. We investigated the association of serum uric acid (sUA) with renal function and the effect of hypouricemic treatment on the rate of renal function decline. METHODS This is a single-center, retrospective,(More)
OBJECTIVE To characterize neuropathic pain in patients with spinal cord injury (SCI) according to classification used in the study by Baron et al. (Baron classification), a classification of neuropathic pain based on the mechanism. To also compare the patterns of neuropathic pain in SCI patients with those in patients with other etiologies and to determine(More)
Adoptive transfer of regulatory T cells (Tregs) can delay disease progression and reduce mortality in lupus-prone mice. Here, we tested whether complex (IL-2C) consisting of IL-2 and anti-IL-2 monoclonal antibody (JES6-1) ameliorates lupus nephritis by expanding Tregs as an alternative to problematic Treg infusion therapy. IL-2C treatment of NZB/W F1 mice(More)
Extracellular adenosine triphosphate (ATP) binds to purinergic receptors and, as a danger molecule, promotes inflammatory responses. Here we tested whether periodate-oxidized ATP (oATP), a P2X7 receptor (P2X7R) antagonist can attenuate renal ischemia-reperfusion injury and clarify the related cellular mechanisms. Treatment with oATP prior to(More)
BACKGROUND Granulocyte colony-stimulating factor (G-CSF) can induce regulatory T cells (Tregs) as well as myeloid-derived suppressor cells (MDSCs). Despite the immune modulatory effects of G-CSF, results of G-CSF treatment in systemic lupus erythematosus are still controversial. We therefore investigated whether G-CSF can ameliorate lupus nephritis and(More)
  • S.-H L, S.-M K, +16 authors Yoo
  • 2013
T he pathogenic role of T cells in the development of hyper-tension has been documented well in recent animal studies. 1 showed that the presence of T cells is a prerequisite for angiotensin II– or desoxycorticosterone acetate salt–induced hypertension in Rag-1 −/− mice. Similarly, Crowley et al 2 found an important role for lymphocytes in angiotensin(More)
Journal bearing misalignment arise generally from the shaft deformation under load, deflection of the shaft, manufacturing and assembly errors, improper installation, and asymmetric loading. During operations, misalignment has a considerable effect on the static and dynamic performances. It could cause wear, vibration and even system failure. In this(More)
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