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We have developed a miniaturized bead-beating device to automate nucleic acids extraction from Gram-positive bacteria for molecular diagnostics. The microfluidic device was fabricated by sandwiching a monolithic flexible polydimethylsiloxane (PDMS) membrane between two glass wafers (i.e., glass-PDMS-glass), which acted as an actuator for bead collision via(More)
DNA metabolic processes such as DNA replication, recombination, and repair are fundamentally important for the maintenance of genome integrity and cell viability. Although a large number of proteins involved in these pathways have been extensively studied, many proteins still remain to be identified. In this study, we isolated DNA-binding proteins from(More)
Microfluidic devices for on-chip amplification of DNA from various biological and environmental samples have gained extensive attention over the past decades with many applications including molecular diagnostics of disease, food safety and biological warfare testing. But the integration of sample preparation functions into the chip remains a major hurdle(More)
Business’ dependency on a software or computer program is getting higher. In such an environment, eliminating security vulnerabilities have become increasingly important and difficult as programs are more complicated and have greater impacts on businesses. We analyzed the security vulnerabilities of code using a symbolic execution engine that tracks data(More)
In this paper, two types of novel planar translational parallel manipulators (TPMs) by using parallelogram mechanism are developed. One is made up of two Pa-P (parallelogram-prismatic) legs connecting the moving platform to the fixed base. The other consists of two P-Pa legs, which is the kinematic inversion of the former. Since connecting links in a(More)
This paper presents the development of a new 6-DOF parallel-kinematic motion simulator. The moving platform is connected to the base by six PUS (Prismatic-Universal-Spherical) serial chains. Comparing with the well-known Stewart-Gough platform-type motion simulator, it uses commercialized linear actuators mounted on the fixed base whereas a 6-UPS(More)
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