Joo Lee Cham

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The rostral ventrolateral medulla (RVLM) is essential for the generation of sympathetic nerve activity. The RVLM receives a substantial innervation from the hypothalamic paraventricular nucleus (PVN). Activation of P2X purinoceptors via ATP has been shown to mediate fast excitatory synaptic neurotransmission. There is mounting evidence to suggest the(More)
Increased sympathetic nerve activity is associated with obesity-related hypertension, but the underlying central neural mechanisms are not clear. We examined the role of the hypothalamic paraventricular nucleus (PVN) in the regulation of sympathetic nerve activity in rats fed a normal chow diet (controls) and rats fed a high-fat diet (36% fat) over 12 wk.(More)
A major integrative site within the brain for autonomic function is the hypothalamic paraventricular nucleus (PVN). Several studies have suggested that the PVN may be involved in the responses regulating body temperature. Hyperthermia elicits redirection of blood flow from the viscera to the periphery and involves changes in sympathetic nerve activity(More)
The present study investigated the effect of acute thermal stimulation in conscious rats on the production of Fos, a marker of increased neuronal activity, in spinally projecting and nitrergic neurons in the hypothalamic paraventricular nucleus (PVN). The PVN contains a high concentration of nitrergic neurons, as well as neurons that project to the(More)
Redistribution of blood from the viscera to the peripheral vasculature is the major cardiovascular response designed to restore thermoregulatory homeostasis after an elevation in body core temperature. In this study, we investigated the role of the hypothalamic paraventricular nucleus (PVN) in the reflex decrease in renal blood flow that is induced by(More)
Cham, Joo Lee, Rudi Klein, Neil C. Owens, Michael Mathai, Michael McKinley, and Emilio Badoer. Activation of spinally projecting and nitrergic neurons in the PVN following heat exposure. Am J Physiol Regul Integr Comp Physiol 291: R91–R101, 2006; doi:10.1152/ajpregu.00675.2005.—The present study investigated the effect of acute thermal stimulation in(More)
Reflex responses to hyperthermia include sweating, salivation and a redirection of blood flow from the viscera to the periphery, and involve changes in peripheral nerve activity mediated by the central nervous system (CNS), including specific areas of the ventral lower brainstem. The lower brainstem contains nitrergic neurones and neurones that project to(More)
The hypothalamic paraventricular nucleus (PVN) is an important integrative center in the brain. In the present study, we investigated whether the PVN is a key region in the mesenteric vasoconstriction that normally accompanies an increase in core body temperature. Anesthetized rats were monitored for blood pressure, heart rate, mesenteric blood flow, and(More)
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