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Parkinson disease (PD) is a common neurodegenerative disorder, which involves the deterioration of dopaminergic neurons in the pars compacta of the substantia nigra. The etiology of PD is still unknown, but recent identification of mutations in familial cases of PD has advanced the understanding of the molecular mechanisms of this neurological disease.(More)
The performance of face recognition methods using subspace projection is directly related to the characteristics of their basis images, especially in the cases of local distortion or partial occlusion. In order for a subspace projection method to be robust to local distortion and partial occlusion, the basis images generated by the method should exhibit a(More)
Lewy bodies (LBs) are pathological hallmarks of Parkinson disease (PD) but also occur in Alzheimer disease (AD) and dementia of LBs. Alpha-synuclein, the major component of LBs, is observed in the brain of Down syndrome (DS) patients with AD. Dyrk1A, a dual specificity tyrosine-regulated kinase (Dyrk) family member, is the mammalian ortholog of the(More)
Power and bandwidth requirements have become more stringent for DRAMs in recent years. This is largely because mobile devices (such as smart phones) are more intensively relying on the use of graphics. Current DDR memory I/Os operate at 5Gb/s with a power efficiency of 17.4mW/Gb/s (i.e., 17.4pJ/b)[1], and graphic DRAM I/Os operate at 7Gb/s/pin [3] with a(More)
—A fully-integrated 8.4 Gb/s 2.5 pJ/b mobile memory I/O transceiver using simultaneous bidirectionaldual band sig-naling is presented. Incorporating both RF-band and baseband transceiver designs, this prototype demonstrates an energy-efficient and high-bandwidth solution for future mobile memory I/O interface. The proposed amplitude shift keying (ASK)(More)
ALpha-synuclein (alpha-syn) has been known to be a key player of the pathogenesis of Parkinson's disease and has recently been detected in extracellular biological fluids and shown to be rapidly secreted from cells. The penetration of alpha-syn into cells has also been observed. In this study, we observed that(More)
—Future inter-and intra-ULSI interconnect systems demand extremely high data rates (up to 100 Gbps/pin or 20-Tbps aggregate) as well as bidirectional multiI/O concurrent service, re-configurable computing/processing architecture, and total compatibility with mainstream silicon system-on-chip and system-in-package technologies. In this paper, we review(More)
A scalable frequency-division multiple access interconnect (FDMA-I) system is proposed to enable reconfigurable and bi-directional multiple I/O chip-to-chip communications. By transmitting signals using N-orthogonal frequency channels, this FDMA-I achieves simultaneous multi-chip access capability between NxN I/Os on a shared bus by selectively switching(More)