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OBJECTIVES Effects of nanoparticles including zinc oxide nanoparticles, titanium oxide nanoparticles, and their mixtures on skin corrosion and irritation were investigated by using in vitro 3D human skin models (KeraSkin ((TM)) ) and the results were compared to those of an in vivo animal test. METHODS Skin models were incubated with nanoparticles for a(More)
SILVER NANOPARTICLES (SIZE 7.9 ± 0.95 nm, dosage: 250 mg/kg) were orally administered to pregnant rats. At 4 days after parturition, four pups were randomly selected (one pup from one dam) and silver level in liver, kidney, lung and brain was determined by ICP-MS and electron microscope. As results, silver nanoparticles highly accumulated in the tissues of(More)
Effects of nanoparticles (NPs) on skin corrosion and irritation using three-dimensional human skin models were investigated based on the test guidelines of Organization for Economic Co-operation and Development (OECD TG431 and TG439). EpiDerm(TM) skin was incubated with NPs including those harboring iron (FeNPs), aluminum oxide (AlNPs), titanium oxide(More)
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