Jonathon T. Olesberg

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We have performed in vivo measurements of near-infrared rat skin absorption in the 4000-5000-cm(-1) spectral range (2.0-2.5-microm wavelength) during a glucose clamp experiment in order to identify the presence of glucose-specific spectral information. Spectra were collected during an initial 3-h period where the animal's blood glucose concentration was(More)
BACKGROUND Selectivity is paramount for the successful implementation of noninvasive spectroscopic sensing for the painless measurement of blood glucose concentrations in people with diabetes. Selectivity issues are explored for different multivariate calibration models based on noninvasive near-infrared spectra collected from an animal model. METHODS(More)
Optical sensing of glucose would allow more frequent monitoring and tighter glucose control for people with diabetes. The key to a successful optical noninvasive measurement of glucose is the collection of an optical spectrum with a very high signal-to-noise ratio in a spectral region with significant glucose absorption. Unfortunately, the optical(More)
BACKGROUND We describe online optical measurements of urea in the effluent dialysate line during regular hemodialysis treatment of several patients. Monitoring urea removal can provide valuable information about dialysis efficiency. METHODS Spectral measurements were performed with a Fourier-transform infrared spectrometer equipped with a flow-through(More)
A temperature-insensitive method for measuring protein concentration in aqueous solutions using near-infrared spectroscopy is described. The method, which is based on identification of the net analyte signal of single-beam spectra, can be calibrated using a single protein absorbance measurement and is thus well suited for crystallization monitoring where(More)
The ex vivo removal of urea during hemodialysis treatments is monitored in real time with a noninvasive near-infrared spectrometer. The spectrometer uses a temperature-controlled acousto optical tunable filter (AOFT) in conjunction with a thermoelectrically cooled extended wavelength InGaAs detector to provide spectra with a 20 cm(-1) resolution over the(More)
We have developed a data acquisition unit (DAU) for continuous, low noise measurement of glucose concentration in subcutaneous interstitial fluid (ISF). The system is comprised of a specialized glucose sensor, analog circuitry for signal conditioning, and delta-sigma ( ) analog to digital converters (ADCs). The glucose sensor has two infrared (IR) LEDs(More)
The performances of a pin versus a pn structure from GaInAsSb materials operating at room temperature are compared both from a theoretical point of view and experimentally. Theoretically, it is found in materials limited by generationrecombination currents, pn junctions have a higher D* than pin junctions. The thinner depletion region of pn junctions(More)
The ideal performance of cascade and noncascade intersubband and interband laser active regions is directly compared in a cavity-insensitive way. For devices not limited by series resistance or series voltage ~such as can in principle be accomplished by cascading! the relevant figure of merit is the net material gain per unit volumetric power dissipation(More)
The production of norovirus virus-like particles (NoV VLPs) displaying NY-ESO-1 cancer testis antigen in Pichia pastoris BG11 Mut(+) has been enhanced through feed-strategy optimization using a near-infrared bioprocess monitor (RTBio(®) Bioprocess Monitor, ASL Analytical, Inc.), capable of monitoring and controlling the concentrations of glycerol and(More)