Jonathon Hott

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Intramuscular injection of botulinum toxin type A (BTX) is used to treat many disorders characterized by muscular spasms. The utility of BTX, however, is limited by its short duration of action, the development of resistance after repeated injections, and cross-reactivity with autonomic neurons. To overcome these limitations, we engineered an immunotoxin(More)
BACKGROUND Image guidance provides additional anatomic information to the surgeon, which may allow more accurate insertion of spinal implants. Imprecise placement of anterior thoracic screws places the spinal cord and paraspinal structures at risk for injury. Image guidance may afford a safety benefit to patients when anterior thoracic screws are required(More)
The use of minimally invasive techniques has not yet been reported for the treatment of recurrent aneurysms after coil embolization. A 47-year-old man with a long history of headaches had an anterior communicating aneurysm that had previously been coil embolized. Three-year follow-up angiography showed a significant recurrence. A 50-year-old woman with(More)
Interferons (IFN) are biologic agents involved in the antiviral response and the inhibition of tumor growth. Biochemical pathways of IFN action include the double-stranded RNA-activated oligoadenylate synthetase, RNase L, and double-stranded RNA-dependent protein kinase (PKR). Extracellular ribonucleases, especially onconase, also display antiviral and(More)
Aetiology and pathogenesis . . . . . . . . . . . . . . 402 Diagnostic approaches . . . . . . . . . . . . . . . . . . . . 403 Clinical manifestations . . . . . . . . . . . . . . . . . 403 Imaging techniques. . . . . . . . . . . . . . . . . . . . 403 Diagnostic thoracentesis . . . . . . . . . . . . . . . . 404 Closed pleural biopsy . . . . . . . . . . . . . .(More)