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The Impact of the Gut Microbiota on Humoral Immunity to Pathogens and Vaccination in Early Infancy
1 Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America, 2 Department of Molecular Genetics and Microbiology, Duke University School ofExpand
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Neutrophils promote tumor resistance to radiation therapy
Significance Many cancer patients are treated with radiation therapy. For some tumors, addition of radiosensitizing chemotherapy improves local control and survival. Some patients treated withExpand
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Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission
ABSTRACT Human cytomegalovirus (HCMV) is the most common congenital infection worldwide and the leading infectious cause of neurologic deficits and hearing loss in newborns. Development of a maternalExpand
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Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus
African green monkeys (AGMs) are natural primate hosts of simian immunodeficiency virus (SIV). Interestingly, features of the envelope-specific antibody responses in SIV-infected AGMs are distinctExpand
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Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys.
Breast milk HIV-1 transmission is currently the predominant contributor to pediatric HIV infections. Yet, only ~10% of breastfeeding infants born to untreated HIV-infected mothers become infected.Expand
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  • Open Access
Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys
ABSTRACT The initial phases of acute human immunodeficiency virus type 1 (HIV-1) infection may be critical for development of effective envelope (Env)-specific antibodies capable of impeding theExpand
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Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys
ABSTRACT Unlike human immunodeficiency virus type 1 (HIV-1)-infected humans, African-origin, natural simian immunodeficiency virus (SIV) hosts, such as African green monkeys (AGMs), sustainExpand
32nd Annual Symposium on Nonhuman Primate Models for AIDS.
Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys
Vertical HIV-1 transmission via breastfeeding is the predominant contributor to pediatric infections that are ongoing in this era of highly effective antiretroviral therapy (ART). Remarkably, onlyExpand
A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy
Despite impressive responses in some patients, immunotherapy fails to cure most cancer patients. Preclinical studies indicate that radiotherapy synergizes with immunotherapy, promotingExpand
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