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BACKGROUND Linkage studies in autism have identified susceptibility loci on chromosomes 2q and 7q, regions containing the DLX1/2 and DLX5/6 bigene clusters. The DLX genes encode homeodomain transcription factors that control craniofacial patterning and differentiation and survival of forebrain inhibitory neurons. We investigated the role that sequence(More)
Clustering is a very well studied problem that attempts to group similar data points. Most traditional clustering algorithms assume that the data is provided without measurement error. Often, however, real world data sets have such errors and one can obtain estimates of these errors. We present a clustering method that incorporates information contained in(More)
OBJECTIVE   To replicate a previously reported association between pollen counts and county suicide rates in the continental United States, across space and time. METHOD   The authors evaluated the relationship between airborne pollen counts and suicide rates in 42 counties of the continental United States, containing a pollen-counting station(More)
Adenoid cystic carcinoma (ACC) is the second most common malignant neoplasm of the salivary glands. Most patients survive more than 5 years after surgery and postoperative radiation therapy. The 10 year survival rate, however, drops to 40%, due to locoregional recurrences and distant metastases. Improving long-term survival in ACC requires the development(More)
Background—These studies were initiated to confirm that high-level thrombomodulin overexpression is sufficient to limit neointima formation after mechanical overdilation injury. Methods and Results—An adenoviral construct expressing thrombomodulin (Adv/RSV-THM) was created and functionally characterized in vitro and in vivo. The impact of local(More)
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