Jonathan Wagner

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In this paper, we first present a linear programming based approach for modeling and solving the resource matching problem in grid environments with heterogeneous resources. The resource matching problem described takes into account resource sharing, job priorities, dependencies on multiple resource types, and resource specific policies. We then propose Web(More)
Grid computing, as a specific model of distributed systems, has sparked recent interest in managing job execution among distributed resource domains. Introduction of the meta-scheduler is a key feature in grid evolution, and the next step is to achieve collaborative interactions between meta-schedulers within and external to organizational boundaries to(More)
In this paper, we first present a linear programming based approach for modeling and solving the resource matching problem in grid environments with heterogeneous resources. The resource matching problem described here takes into account resource sharing, job priorities, dependencies on multiple resource types, and resource specific policies. We then(More)
The dose-exposure-response relationship for drugs may differ in pediatric patients compared with adults. Many clinical studies have established drug dose-exposure relationships across the pediatric age spectrum; however, genetic variation was seldom included. This article applies a systematic approach to determine the relative contribution of development(More)
An 8-year-old boy with hypoplastic left heart syndrome with a previous history of thrombosis within the inferior vena cava receiving stable warfarin dosing for anticoagulation was diagnosed with influenza B. He was subsequently placed on oseltamivir therapy according to the Centers for Disease Control and Prevention clinical practice guidelines. During the(More)
A 24-year-old male with a history of psychiatric disorder and no prior significant temporomandibular joint (TMJ) pathology presented to the emergency department for "lockjaw." Plain film X-rays of the mandible were read as unremarkable by an attending radiologist, leading to the initial diagnosis of medication-induced dystonic reaction. Following(More)
We present an overview of the software architecture for a shared virtual environment that supports both user-generated content and time navigation. The novel combination of these features into a shared virtual environment necessitates fundamental augmentation to established techniques for building such software systems. A survey of related work describes(More)
We describe a unique presentation of arrhythmogenic right ventricular dysplasia (ARVD) in a 14-year-old Caucasian male who was additionally diagnosed with long QT syndrome (LQTS). Genetic testing eventually confirmed the diagnosis of both ARVD and LQTS, which combined, to our knowledge, has not been reported in the literature.
Increasingly, children and adolescents with dyslipidemia qualify for pharmacologic intervention. As they are for adults, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins) are the mainstay of pediatric dyslipidemia treatment when lifestyle modifications have failed. Despite the overall success of these drugs, the magnitude of variability(More)
OBJECTIVES After reading this article, the reader should be able to 1. Realize that volume of distribution, elimination clearance, and elimination half-life are crucial parameters of pharmacokinetics that must be understood to determine clinical pharmacologic decisions.2. Know that drug disposition is a complicated process of absorption,(More)