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Role of soluble epoxide hydrolase in age-related vascular cognitive decline.
P450 eicosanoids are important regulators of the cerebral microcirculation, but their role in cerebral small vessel disease is unclear. We tested the hypothesis that vascular cognitive impairmentExpand
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The START App: a web‐based RNAseq analysis and visualization resource
Summary: Transcriptional profiling using RNA sequencing (RNAseq) has emerged as a powerful methodology to quantify global gene expression patterns in various contexts from single cells to wholeExpand
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Soluble Epoxide Hydrolase: Sex Differences and Role in Endothelial Cell Survival
Objective—Sex differences in cerebral ischemic injury are, in part, arrtibutable to the differences in cerebrovascular perfusion. We determined whether the brain microvascular endothelial cells (ECs)Expand
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Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid.
Epoxyeicosatrienoic acids (EETs) are potent vasodilators that play important roles in cardiovascular physiology and disease, yet the molecular mechanisms underlying the biological actions of EETs areExpand
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Soluble Epoxide Hydrolase Dimerization Is Required for Hydrolase Activity*
Background: Soluble epoxide hydrolase (sEH) forms a homodimer that metabolizes a neuroprotective class of lipids termed epoxyeicosatrienoic acids. Results: Mutations on the dimerization interface ofExpand
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Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation After Subarachnoid Hemorrhage
Background and Purpose— Acute communicating hydrocephalus and cerebral edema are common and serious complications of subarachnoid hemorrhage (SAH), whose causes are poorly understood. Using a mouseExpand
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  • Open Access
Genetic variation in soluble epoxide hydrolase: association with outcome after aneurysmal subarachnoid hemorrhage.
OBJECT Patients with aneurysmal subarachnoid hemorrhage (SAH) are at high risk for delayed cerebral ischemia (DCI) and stroke. Epoxyeicosatrienoic acids (EETs) play an important role in cerebralExpand
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  • Open Access
Measurement Science in the Circulatory System
The dynamics of the cellular and molecular constituents of the circulatory system are regulated by the biophysical properties of the heart, vasculature and blood cells and proteins. In this review,Expand
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Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway.
BACKGROUND The familial hyperkalemic hypertension (FHHt) cullin 3 (CUL3) mutant does not degrade WNK kinases normally, thereby leading to thiazide-sensitive Na-Cl cotransporter (NCC) activation. CUL3Expand
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Disrupting Dimerization Translocates Soluble Epoxide Hydrolase to Peroxisomes
The epoxyeicosatrienoic acid (EET) neutralizing enzyme soluble epoxide hydrolase (sEH) is a neuronal enzyme, which has been localized in both the cytosol and peroxisomes. The molecular basis for itsExpand
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  • Open Access