Jonathan W Dube

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Spindles and slow waves are hallmarks of non-rapid eye movement sleep. Both these oscillations are markers of neuronal plasticity, and play a role in memory and cognition. Normal ageing is associated with spindle and slow wave decline and cognitive changes. The present study aimed to assess whether spindle and slow wave characteristics during a baseline(More)
Sleep spindles are a hallmark of NREM sleep. They result from a widespread thalamo-cortical loop and involve synchronous cortical networks that are still poorly understood. We investigated whether brain activity during spindles can be characterized by specific patterns of functional connectivity among cortical generators. For that purpose, we developed a(More)
Sleep slow waves (SWs) change considerably throughout normal aging. In humans, SWs are generated and propagate on a structural backbone of highly interconnected cortical regions that form most of the default mode network, such as the insula, cingulate cortices, temporal lobe, parietal lobe, and medial frontal lobe. Regions in this network undergo cortical(More)
Cyclobenzaprine hydrochloride became available for the treatment of acute skeletal muscle spasm ten years ago. The initial clinical trials conducted during the premarketing evaluation of this drug showed that it was significantly superior to placebo in relieving the signs and symptoms of acute skeletal muscle spasm. In addition, cyclobenzaprine was found to(More)
The synthesis and structural characterization of dicationic selenium and tellurium analogues of the carbodiphosphorane and triphosphenium families of compounds are reported. These complexes, [Ch(dppe)][OTf](2) [Ch = Se, Te; dppe = 1,2-bis(diphenylphosphino)ethane; OTf = trifluoromethanesulfonate], are formed using [Ch](2+) reagents via a ligand-exchange(More)
The bis(phosphino)borate ligand class is used as an anionic anchor to stabilize reactive, low coordinate arsenic centers. The neutral, zwitterionic As(I) species, 2, is formed very cleanly, and isolated in good yields using cyclohexene as a halogen scavenger. The uniqueness of this heterocyclic As(I) compound is on display with the coordination to Group 6(More)
The differing structures and reactivities of "GaI" samples prepared with different reaction times have been investigated in detail. Analysis by FT-Raman spectroscopy, powder X-ray diffraction, (71)Ga solid-state NMR spectroscopy, and (127)I nuclear quadrupole resonance (NQR) provides concrete evidence for the structure of each "GaI" sample prepared. These(More)
Analytically pure chloride and bromide salts of two different cyclic triphosphenium cations are prepared by the reaction of PX3 (X=Cl, Br) in the presence of the halogen-scavenging reagent cyclohexene. For the brominated species, the neutral, volatile 1,2-dibromocyclohexane byproduct is readily removed under reduced pressure, and the desired salts are(More)
A series of structurally differentiated cationic arsines containing imidazolium, cyclopropenium, formamidinium, and pyridinium substituents have been synthesized through short and scalable routes. Evaluation of the donor properties of these compounds by IR spectroscopy and DFT calculations reveals similar σ-electron-releasing abilities for all of them;(More)
A straightforward route for the preparation of a set of bis(cyclopropenium)-substituted phosphines is reported. Due to their dicationic nature, these ligands depict an excellent π-acceptor character. The effect of the ligand substituent pattern on the catalytic activity of the metal complexes thereof derived is also studied. Whereas sterically demanding(More)